微阵列比较基因组杂交技术及其在成年人急性白血病中的研究进展  

Research progress of array-comparative genomic hybridization in adult acute leukemia

作　　者：魏彰悦 朱丽霞[1] 叶琇锦[1] Wei Zhangyue, Zhu Lixia, Ye Xiujin(Department of Hematology, First Affiliated Hospital of Medical School of Zhejiang University, Hangzhou 310003, Zhejiang Province, Chin)

机构地区：[1]浙江大学医学院附属第一医院血液科,杭州310003

出　　处：《国际输血及血液学杂志》2018年第1期55-59,共5页International Journal of Blood Transfusion and Hematology

基　　金：浙江省科技厅科技计划项目（2016C33137）

摘　　要：微阵列比较基因组杂交（a—CGH）技术在检测基因拷贝数异常（CNA）方面具有显著优势，在针对智力低下、多发性先天畸形等的产前遗传学诊断，以及胰腺肿瘤、宫颈癌、胃癌、肺癌等多种实体肿瘤的诊断中均有广泛应用，并且在成年人急性白血病（AL）中亦有着良好应用前景。笔者拟就a—CGH技术应用于急性淋巴细胞白血病（ALL）、急性髓细胞白血病（AML）及混合表型急性白血病（MPAL）的诊断、治疗、预后及耐药机制研究的进展进行综述，旨在为进一步认识AL的发生、发展过程，以及为更深入研究AL的基因靶向治疗提供新方向。Array-comparative genomic hybridization （a-CGH） technology has significant advantages in detecting abnormal gene copy number alteration （CNA）, especially for prenatal diagnosis of mental retardation and multiple congenital malformations, and diagnosis of pancreatic cancer, cervical cancer, gastric cancer, lung cancer and other tumors. What＇s more, it also has a good application prospect in adult acute leukemia （AL）. This review focuses on the application of a-CGH technology in the diagnosis, treatment and prognosis of acute lymphocytic leukemia （ALL）, acute myeloid leukemia （AML）, mixed phenotype acute leukemia （MPAL）, and exploring drug-resistance mechanisms. It will provide a new direction for further understanding of the occurrence and development of AL, as well as further research on gene targeting therapy of AL.

关 键 词：微阵列分析 比较基因组杂交 白血病 成年人 

分 类 号：R733.71[医药卫生—肿瘤]