Myocardin分子亚型、表达及活性调控机制的研究进展  

Molecular subtypes, expression and regulatory mechanisms of myocardin

作　　者：哈艳平 王可可 揭伟 HA Yan-ping, WANG Ke-ke, JIE Wei(Department of Pathology, School of Basic Medical Sciences, Guangdong Medical University, Zhanjiang 524023, Chin)

机构地区：[1]广东医科大学基础医学院病理学系,广东湛江524023

出　　处：《广东医科大学学报》2017年第5期453-461,共9页Journal of Guangdong Medical University

基　　金：国家自然科学基金项目(No.81170121;No.81670254);广东省"扬帆计划"人才项目(No.4YF16007G);广东省科技计划项目(No.2016A020214016)

摘　　要：心肌素(Myocardin)通过与血清反应因子(SRF)结合成蛋白复合物,调节具有cArG-box基因的转录,主要介导心肌细胞及平滑肌细胞的分化。Myocardin表达与活性异常与许多心血管疾病密切关联。该文主要对Myocardin分子结构亚型、表达及活性调节的研究进展进行了综述。Myocardin regulates the transcription of downstream genes archived with CArG-box through cooperation with serum response factor（SRF）, and mainly mediates the differentiation of cardiomyocytes and smooth muscle cells. The abnormalities of myocardin expression and activity are closely related to many cardiovascular diseases. This paper aims to summarize the advances on the molecular subtypes, expression and regulatory mechanisms of myocardin.

关 键 词：MYOCARDIN 分子亚型 调控机制 

分 类 号：Q291[生物学—细胞生物学] R394.3[医药卫生—医学遗传学]