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A shared role of the myocardin-family transcriptional coactivators in cardiomyocyte maturation: 《Science China(Life Sciences)》2023年第12期2939-2942,共4页Yuxuan Guo Yangpo Cao Blake D.Jardin Neil Mazumdar Congting Guo Luzi Yang Junsen Lin Zhan Chen Qing Ma Mingming Zhao Erdan Dong William T.Pu; supported by the National Key Research and Development Program of China (2022YFA1104800);the National Natural Science Foundation of China (82222006,32100660,82170367);Beijing Nova Program (Z211100002121003,20220484205);Beijing Natural Science Foundation (7232094);supported by National Institute of Health (R01HL146634 and UM1HL098166);supported by the Natural Science Foundation of China (82070235 and 92168113);the CAMS Innovation Fund for Medical Sciences (2021-I2M-5003);Haihe Laboratory of Cell Ecosystem Innovation Fund (HH22KYZX0047)。; Dear Editor,In development,after cells make a commitment to their fates,they undergo a continuous and adaptive maturation process to eventually reach their terminal states.Cell maturity often decays during aging and p...; 关键词：STATES eventually DECAY

低氧刺激通过HIF-1α直接调节Myocardin表达促进骨髓间充质干细胞向心肌样细胞分化被引量：2: 《临床与实验病理学杂志》2021年第9期1038-1043,共6页哈艳平刘晓晓邵钟铭邹园伍彩霞郭峻莉申志华揭伟; 国家自然科学基金(81170121)。; 目的探讨低氧刺激在骨髓间充质干细胞(bone marrow mesenchymal stem cells,BMSC)向心肌细胞谱系分化过程中对心肌素(Myocardin)表达的影响及机制。方法分离Sprague Dawley大鼠股骨BMSC,磁激活细胞分选法获得c-Kit^(+)细胞亚群。分别用H...; 关键词：骨髓间充质干细胞心肌样细胞分化低氧 HIF-1Α MYOCARDIN

Overexpression of Myocardin-related transcription factor-A attenuated middle cerebral artery occlusion/reperfusion-induced apoptosis via the Mcl-1/Cyt C/cleaved caspase 3 pathway被引量：1: 《Journal of Innovative Optical Health Sciences》2019年第6期199-209,共11页Zhi-Jun Yu Jing Du Wei Zhang Shu-Qi Zhao Wei Dong Shi-Qiang Xu Ling Hu Zhen-Li Min Qiong Yuan Chunxiang Zhang Xia-Min Hu; supported by the National Nature Science Foundation of China(Nos.31171327 and 81770377);the Nature Science Foundation of Hubei Province(No.2017CFB448).; To investigate the effect of Myocardin related transcription factor A(MRTF-A)on apoptosis induced by ischemic/reperfusion(I/R),middle cerebral artery occlusion/reperfusion(MCAO/R)in rats were applied to mimic I/R.The ...; 关键词：Stroke animal model immunofuorescence staining laser scanning confocal microscope

Liuwei Dihuang soft capsules inhibits phenotypic conversion of VSMCs via up-regulating expression of myocardin by promoting interaction between ERα and SRC3: 《中国药理学与毒理学杂志》2019年第9期694-695,共2页MENG Qing-hai YU Xi-chao CHEN Qi KONG Xue-yun CHENG Peng LI Yu BIAN Hui-min; National Natural Science Foundation of China(81773190;81774029);Jiangsu Provincial Science and Technology Department Social Development Fund(BE2011846); OBJECTIVE To reveal the under mechanism of how Liuwei Dihuang(LWDH)inhibits the phenotypic con⁃version of VSMCs.METHODS 24 ApoE-/-mice were divided into 4 groups:sham group,model group,E2 group,and LWDH group.Six C57B...; 关键词：Liuwei Dihuang VSMC atherosclerosis MENOPAUSE ER MYOCARDIN

myocardin通过激活miR-93-5p促进人主动脉血管平滑肌细胞分化被引量：1: 《天津科技大学学报》2019年第2期19-24,共6页史丹阳刘美玲刘翔张建张同存王楠; 天津市自然科学基金资助项目(17JCZDJC33600);天津市高等学校创新团队培养计划资助项目(TD13-5015); myocardin是促进平滑肌细胞分化的重要转录因子.微小RNA(microRNAs,miRNA)在近年来已经证实参与多种生物学过程,包括平滑肌的表型转化.然而在平滑肌分化过程中myocardin与哪些microRNA具有相关性仍有待于阐明.通过将外源性myocardin转...; 关键词：MYOCARDIN 人主动脉血管平滑肌细胞表型转化 miR-93-5p

Myocardin重组蛋白表达及其在人骨髓间充质干细胞重编程为血管平滑肌细胞中的作用被引量：1: 《中国病理生理杂志》2018年第8期1409-1414,共6页麦丽萍杨翔宇吴岳恒余细勇何国东李晓红; 广东省科技计划(No.2017A070701013;No.2017B090904034); 广州市科技计划(No.201704020126); 目的:研究心肌素(myocardin)重组蛋白的表达及分离纯化方法,并探讨myocardin重组蛋白对人骨髓间充质干细胞(human bone marrow mesenchymal stem cells,h BMSCs)向血管平滑肌细胞转分化的作用。方法:构建myocardin原核表达载体,摸索最...; 关键词：心肌素重组蛋白平滑肌肌球蛋白重链骨髓间充质干细胞细胞重编程

miR-219a-5p inhibits breast cancer cell migration and epithelial-mesenchymal transition by targeting myocardin-related transcription factor A被引量：6: 《Acta Biochimica et Biophysica Sinica》2017年第12期1112-1121,共10页; Although many miRNAs are reported to be involved in tumor formation and progression, the effect of miR-219a-5p on breast cancer metastasis is not well-known. The aim of this study is to investi- gate the effect of miR...; 关键词：breast cancer cell migration epithelial-mesenchymal transition miR-219a-5p myocardin-related transcription factor A

Curcumin enhances vascular contractility via induction of myocardin in mouse smooth muscle cells被引量：3: 《Acta Pharmacologica Sinica》2017年第10期1329-1339,共11页Shao-wei SUN Wen-juan TONG Zi-fen GUO Qin-hui TUO Xiao-yong LEI Cai-ping ZHANG Duan-fang LIAO Jian-xiong CHEN; A variety of cardiovascular diseases is accompanied by the loss of vascular contractility. This study sought to investigate the effects of curcumin, a natural polyphenolic compound present in turmeric, on mouse vascul...; 关键词：CURCUMIN smooth muscle vascular contractility MYOCARDIN caveolin-l NOTCHL

Myocardin分子亚型、表达及活性调控机制的研究进展被引量：1: 《广东医科大学学报》2017年第5期453-461,共9页哈艳平王可可揭伟; 国家自然科学基金项目(No.81170121;No.81670254);广东省"扬帆计划"人才项目(No.4YF16007G);广东省科技计划项目(No.2016A020214016); 心肌素(Myocardin)通过与血清反应因子(SRF)结合成蛋白复合物,调节具有cArG-box基因的转录,主要介导心肌细胞及平滑肌细胞的分化。Myocardin表达与活性异常与许多心血管疾病密切关联。该文主要对Myocardin分子结构亚型、表达及活性调节...; 关键词：MYOCARDIN 分子亚型调控机制

GSNO通过亚硝酰化抑制Myocardin诱导的心肌肥厚: 《天津科技大学学报》2017年第4期30-35,共6页郑德亮廖兴华魏兆强杜福周浩张同存; 国家自然科学基金资助项目(31171303); Myocardin可以诱导心肌肥厚,而一氧化氮(NO)对于心肌具有一定保护作用,但在心肌肥厚发生的过程中,NO的作用尚未报道.本文首先用NO荧光探针检测亚硝基谷胱甘肽(S-Nitrosoglutathione,GSNO)处理能够引起H9c2细胞中NO总含量的上升.随后利用...; 关键词：亚硝酰化 MYOCARDIN GSNO GSNOR

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