Objective To study the mechanistic role of myeloid-specific Notchl knockout inhibiting STING signaling to regulate hepatocyte lipophagy.Methods A mouse model of nonalcoholic steatohepatitis(NASH)was established using ...
the National Natural Science Foundation of China(No.81801621,No.81572723,No.81872253).
The molecular mechanisms underlying the development of intrahepatic cholangiocarcinoma(ICC)are not clear yet.In this study,we investigated the involvement of Notch1 in the development of ICC.The cDNA microarray analys...
financially supported by the National Natural Science Foundation of China (No. U1401242);National Basic Research Program of China (No. 2015CB755500);the Guangdong Innovative and Entrepreneurial Research Team Program (No. 2013S086);the Fundamental Research Funds for the Central Universities (Nos. 17lgjc01 and 17lgpy08)
Chronic inflammatory responses induced by macrophages play a pivotal role in the progression of atherosclerosis. In the present study, a multifunctional nanocarrier based on poly(ethylene glycol)-block-poly(L-aspar...