p33^(ING1)在胃癌中的表达及其临床意义  

The expression level of p33^(ING1) in gastric cancer and its clinical significance

作　　者：朱博[1] 宋超[1] 王丹娜[1] 俞岚[1] 赵艳[1] 陶仪声[1] ZHU Bo;SONG Chao;WANG Dan-na;YU Lan;ZHAO Yan;TAO Yi-sheng(Department of Pathology, The First Affiliated Hospital of Bengbu Medical College, Department of Pathology, Bengbu Medical College, Bengbu Anhui 233004, Chin)

机构地区：[1]蚌埠医学院第一附属医院病理科蚌埠医学院病理学教研室,安徽蚌埠233004

出　　处：《蚌埠医学院学报》2018年第2期160-163,167,共5页Journal of Bengbu Medical College

基　　金：安徽省高校自然科学研究重点项目(KJ2017A224);蚌埠医学院自然科学基金重点项目(BYKY1711ZD)

摘　　要：目的:检测人胃癌组织中生长抑制因子p33^(ING1)的表达情况,并探讨其与胃癌病人临床病理参数之间的关系。方法:采用免疫组织化学(ElivisionTMplus法)检测胃癌组织91例、正常胃黏膜30例和不典型增生胃黏膜组织35例中p33^(ING1)蛋白的表达情况。结果:在胃癌组织中,p33^(ING1)蛋白表达的阳性率均明显低于正常胃黏膜和不典型增生胃黏膜(P<0.01)。胃癌组织中p33^(ING1)蛋白的表达情况在不同肿瘤的浸润深度、分化程度、临床分期和淋巴结有无转移间差异均有统计学意义(P<0.05)。应用生存曲线的Log-rank单因素分析显示:浸润深度和淋巴结转移与胃癌的预后均有一定相关性,而p33^(ING1)与胃癌的预后可能无相关性。结论:p33^(ING1)在胃癌组织中表达异常,可能与胃癌的发展有关,有望为胃癌提供新的治疗靶点。Objective： To detect the expression level of p33ING1 in human gastric cancer tissue,and investigate the relationship between p33ING1 level and clinicopathologic characteristics. Methods： The expression levels of p33ING1 in 91 gastric cancer samples,30 normal gastric mucosa tissue samples and 35 atypical hyperplasia tissue samples were detected using immunohistochemical staining method.Results： The positive rate of p33ING1 protein in gastric carcinoma tissue was higher than that in normal gastric tissue and atypical hyperplasia tissue（ P〈 0. 01）. The differences of the p33ING1 protein levels in gastric carcinoma tissue with different depth of invasion,grade of tumor,lymph node metastasis and Duke＇ s stages were statistically significant（ P〈 0. 05）. The results of Log-rank test of survival curves showed that the depth of invasion and lymph node metastasis of gastric cancer were related to prognosis,and the expression level of p33ING1 was not related to prognosis. Conclusions： The abnormal expression of p33^（ING1） in the gastric tissue may be associated with the development of gastric cancer,which is expected to provide a new target for the treatment of gastric cancer.

关 键 词：胃肿瘤 生长抑制因子 免疫组织化学法 

分 类 号：R735[医药卫生—肿瘤]