重视女性生殖道微生态与宫颈病变关系的研究  

The relationship between genital tract microecology and cervical lesions should be emphasized

作　　者：葛雪飞[1] 耿力[1] Ge Xuefei;Geng Li(Department of Obsterics and Gynecology, Peking University Third Hospital, Beijing 100191, China)

机构地区：[1]北京大学第三医院妇产科,100191

出　　处：《中华检验医学杂志》2018年第4期267-269,共3页Chinese Journal of Laboratory Medicine

基　　金：国家自然科学基金（81472429）

摘　　要：由于宫颈解剖位置的特殊性，宫颈上皮不可避免地受到阴道微生态的影响。阴道微生态失平衡不仅引起阴道炎，还与HPV感染和宫颈癌相关。目前宫颈癌和癌前病变主要与少数高危型HPV持续感染相关，其中HPV16、18引起全世界70％的宫颈癌，因此HPV检测在宫颈癌筛查及治疗后随访中意义重大，而临床上HPV检测的目的在于检出宫颈癌和癌前病变，故要求HPV检测方法应设立以CIN2＋病变为终点的HPV阳性阈值。综上，了解阴道微生态、HPV感染和宫颈癌及癌前病变的关系，明确HPV检测的目的，将有助于临床医生开展宫颈癌和癌前病变的诊疗工作。The cervical epithelium can be affected by vaginal microecosystem inevitably, for the specificity of the cervical anatomy. HPV infection and cervical cancer, as well as vaginitis are associated with the imbalance of vaginal microeeosystem. High-risk HPV infection is closely related to cervical cancer and precancerous lesions, with HPV16 and HPV18 causing 70% cervical cancer worldwide. Therefore, HPV test is significant in cervical cancer screening and follow-up. However, HPV test is used for cervical cancer or precancerous lesions detection clinically. In consequence, a threshold of HPV test for CIN2 ＋ lesions evaluation should be set. In conclusion, it is important to understand the relationship among vaginal microecosystem, HPV infection and cervical cancer and precancerous lesions. Clinicians should know the purpose of HPV detection, which will contribute to clinical diagnosis and treatment of cervical cancer and nrecancerous lesions.

关 键 词：阴道 微生物群 乳头状瘤病毒科 宫颈肿瘤 宫颈上皮内瘤样病变 乳头状瘤病毒感染 

分 类 号：R730.43[医药卫生—肿瘤] R737.33[医药卫生—临床医学]