大蝎子草地上部分化学成分研究  

Chemical Constituents from the Aerial Parts of Girardinia diversifolia

作　　者：张嫩玲[1,2] 田婷婷 田璧榕 吴林菁[1,2] 陶玲[1,2] 沈祥春[1,2] ZHANG Nenling;TIAN Tingting;TIAN Birong;WU Linjing;TAO Ling;SHEN Xiangchun(The High Educational Key Laboratory of Guizhou Province for Natural Medicinal Pharmacology and Druggability,Guizhou Medical University,Guiyang 550025,Guizhou,China;The Union Key Laboratory of Guiyang City ＆ Guizhou Medical University,Guiyang 550025,Guizhou,China)

机构地区：[1]贵州医科大学贵州省高等学校天然药物药理与成药性评价特色重点实验室,贵州贵阳550025 [2]贵阳市一贵州医科大学联合实验室,贵州贵阳550025

出　　处：《贵州医科大学学报》2018年第5期538-539,545,共3页Journal of Guizhou Medical University

基　　金：贵州省卫生计生委科学技术基金项目(gzwjkj2014-2-103);贵州省科技厅-贵州医科大学联合基金项目[黔科合LH字(2015)7339]

摘　　要：目的:研究大蝎子草地上部分的化学成分。方法:采用硅胶柱层析、Sephadex LH-20凝胶层析及MCI柱层析及结晶、重结晶方法分离纯化大蝎子草地上部分化合物,并运用波谱及化学方法对所分得的化合物进行结构鉴定。结果:从大蝎子草地上部分分离纯化得到5个化合物,经波谱解析鉴定为尿嘧啶、儿茶酚、5-硝基愈创木酚、β-谷甾醇及草酸,除化合物β-谷甾醇外均为首次从大蝎子草地上部分分离得到。结论:大蝎子草地上部分成分有尿嘧啶、儿茶酚、5-硝基愈创木酚、β-谷甾醇及草酸。Objective： To study the chemical constituents from the aerial parts of Girardinia diversifolia. Methods： The constituents were isolated by column chromatography,and structures of the isolated compounds were identified by spectroscopic and chemical means. Results： Five compounds were isolated from the aerial parts of Girardinia diversifolia and identified as uracil,catechol,5-nitroguajacol,β-sitosterol and oxalic acid. Conclusions： All the compounds except β-sitosterol are extracted from Girardinia diversifolia for the first time.

关 键 词：大蝎子草 荨麻科 层析法 化学成分 酚类 硅胶柱层析 凝胶层析 

分 类 号：R914.4[医药卫生—药物化学]