PAK4与肿瘤关系的研究进展  

The association of PAK4 and tumors

作　　者：马一鸣 李晓东[2] MA Yi-ming;LI Xiao-dong(The Second Clinical College, The 100th Stages, Class 81;Molecular Cell Biology Teaching and Research, China Medical University Shenyang Liaoning 110012, China)

机构地区：[1]中国医科大学第二临床学院,辽宁沈阳110012 [2]中国医科大学分子细胞生物学教研室,辽宁沈阳110012

出　　处：《解剖科学进展》2018年第3期330-333,共4页Progress of Anatomical Sciences

基　　金：国家自然科学基金重点项目(81230077)

摘　　要：P21活化蛋白激酶(p-21 activated protein kinase,PAK)是一类进化上保守的丝氨酸/苏氨酸蛋白激酶,是Rho家族Cdc42和Rac的效应蛋白。PAK4是PAK家族II类成员的代表,可被生长因子及其他胞外信号活化,并通过众多的下游结合蛋白或激酶底物,调节控制许多生物学功能,如:肿瘤生长、细胞骨架重组、基因转录调控等,特别是在细胞的恶性转化和肿瘤细胞侵袭转移过程中具有重要作用,因此成为肿瘤治疗新的靶点。P21 activated protein kinases（PAKs） are evolutionarily conserved serine/threonine protein kinase and effectors of Rho family Cdc42 and Rae. PAK4 is a member of the group II PAK family, which is activated by growth factors and other extracellular signals and regulates many biological functions such as： tumor growth, cytoskeletal reorganization, and transcriptional regulation, among other things. PAK4 plays an imporlant role in the malignant transformation of cells and invasion and metastasis of tumor cells, and thus becomes a new target for tumor therapy.

关 键 词：肿瘤细胞 磷酸化 细胞骨架 信号通路 小分子抑制剂 

分 类 号：R730.2[医药卫生—肿瘤]