ZNF804A Variation May Affect Hippocampal-Prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals  

作　　者：Yuyanan Zhang Hao Yan Jinmin Liao Hao Yu Sisi Jiang Qi Liu Dai Zhang Weihua Yue 

机构地区：[1]Institute of Mental Health, Peking University Sixth Hospital,Beijing 100191, China [2]Key Laboratory of Mental Health, Ministry of Health and National Clinical Research Center for Mental Disorders(Peking University), Beijing 100191, China [3]Department of Psychiatry, Jining Medical University,Jining 272067, China [4]Peking-Tsinglaua Joint Center for Life Sciences and PKUIDG/McGovern Institute for Brain Research, Peking University, Beijing 100871, China

出　　处：《Neuroscience Bulletin》2018年第3期507-516,共10页神经科学通报（英文版）

基　　金：supported by the National Key Research and Development Program of China (2016YFC1307000 and 2015BAI13B01);the National Natural Science Foundation of China (91432304, 81370032, 81571313 and 81221002);Capital Health Development Research (2016-2-4112);Beijing Nova Program Interdisciplinary Studies Cooperative Project (Z161100004916038)

摘　　要：The ZNF804 A variant rs1344706 has consistently been associated with schizophrenia and plays a role in hippocampal-prefrontal functional connectivity during working memory. Whether the effect exists in the resting state and in patients with schizophrenia remains unclear. In this study, we investigated the ZNF804 A polymorphism at rs1344706 in 92 schizophrenic patients and 99 healthy controls of Han Chinese descent, and used resting-state functional magnetic resonance imaging to explore the functional connectivity in the participants. We found a significant main effect of genotype on the resting-state functional connectivity（RSFC） between the hippocampus and the dorsolateral prefrontal cortex（DLPFC） in both schizophrenic patients and healthy controls. The homozygous ZNF804 A rs1344706 genotype（AA） conferred a high risk of schizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC（F（2,165） = 13.43,P ／ 0.001）. The RSFC strength was also correlated with cognitive performance and the severity of psychosis in schizophrenia. The current findings identified the neural impact of the ZNF804 A rs1344706 on hippocampalprefrontal RSFC associated with schizophrenia.The ZNF804 A variant rs1344706 has consistently been associated with schizophrenia and plays a role in hippocampal-prefrontal functional connectivity during working memory. Whether the effect exists in the resting state and in patients with schizophrenia remains unclear. In this study, we investigated the ZNF804 A polymorphism at rs1344706 in 92 schizophrenic patients and 99 healthy controls of Han Chinese descent, and used resting-state functional magnetic resonance imaging to explore the functional connectivity in the participants. We found a significant main effect of genotype on the resting-state functional connectivity（RSFC） between the hippocampus and the dorsolateral prefrontal cortex（DLPFC） in both schizophrenic patients and healthy controls. The homozygous ZNF804 A rs1344706 genotype（AA） conferred a high risk of schizophrenia, and also exhibited significantly decreased resting functional coupling between the left hippocampus and right DLPFC（F（2,165） = 13.43,P ／ 0.001）. The RSFC strength was also correlated with cognitive performance and the severity of psychosis in schizophrenia. The current findings identified the neural impact of the ZNF804 A rs1344706 on hippocampalprefrontal RSFC associated with schizophrenia.

关 键 词：SCHIZOPHRENIA ZNF804A Imaging genetics HIPPOCAMPUS Dorsolateral prefrontal cortex 

分 类 号：R749.3[医药卫生—神经病学与精神病学] X503.1[医药卫生—临床医学]