Synaptotagmins： links to human disease  

作　　者：Wanru Li Claire Xi Zhang 

机构地区：[1]Center of Parkinson's Disease,Beijing Institute for Brain Disorders,Capital Medical University,Key Laboratory for the Neurodegenerative Disorders of the Chinese Ministry of Education,Beijing 100069,China

出　　处：《Journal of Translational Neuroscience》2017年第4期24-30,共7页转化神经科学电子杂志（英文）

基　　金：The author was supported by grants from the Beijing Natural Science Foundation Program and the Scientifc Research Key Program of Beijing Municipal Commission of Education （KZ201510025023）, the National Natural Science Foundation of China （31471085）.

摘　　要：Synaptotagmins （Syts） are a large family of integral membrane proteins that regulate synaptic function and membrane traffcking. Emerging evidences show involvement of Syts in human diseases. Here, we review the recent studies of several Syts （Syt1, 2, 7, 11, and 14） in the pathophysiological mechanisms of neurodegeneration disorders such as Alzheimer’s disease, Parkinson’s disease, and attention-defcit/hyperactivity disorder etc. A better understanding of the diverse physiological and pathological functions of different Syt isoforms is needed for potential therapeutic interventions in the future.

关 键 词：synaptotagmins （Syts） NEURODEGENERATION 

分 类 号：R0[医药卫生]