EGFR、MTDH、ERCC1在口腔特殊亚型的鳞状细胞癌中的表达及临床意义  

Expression and Clinical Significance of EGFR,MTDH,and ERCC1 in Special Subtypes of Oral Squamous Carcinoma

作　　者：陈蔚华[1] 裴婧[1] 贾云香[1] CHEN Wei-hua;PEI Jing;JIA Yun-xiang(Department of Pathology, Affiliated Stomatological Hospital of Nanchang University, The Key Laboratory of Oral Biomedicine of J iangxi Province, Nanchang 330006, China)

机构地区：[1]南昌大学附属口腔医院病理科、江西省口腔生物医学重点实验室,江西南昌330006

出　　处：《口腔医学研究》2018年第6期623-626,共4页Journal of Oral Science Research

基　　金：江西省科技厅社会发展科技支撑项目(编号：20111BBG70027-5)

摘　　要：目的:探讨EGFR、MTDH、ERCC1在口腔特殊亚型的鳞状细胞癌(简称鳞癌)中的表达意义,为其治疗提供依据。方法:运用免疫组化二步法检测口腔特殊亚型鳞状细胞癌的EGFR、MTDH、ERCC1的表达情况。结果:口腔腺鳞癌比基底样鳞癌、乳头状鳞癌和梭形细胞癌中的EGFR表达高,后三者又比疣状癌的表达高(P<0.05);腺鳞癌比基底样鳞癌、乳头状鳞癌和疣状癌中的MTDH、ERCC1表达高,后三者又比梭形细胞癌的表达高(P<0.05);腺鳞癌比基底样鳞癌的淋巴结转移率高,基底样鳞癌比乳头状鳞癌、梭形细胞癌和疣状癌的淋巴结转移率高(P<0.05)。结论:EGFR、MTDH和ERCC1的表达水平可以作为评估口腔特殊亚型鳞状细胞癌种类的重要生物学指标,为口腔特殊亚型鳞状细胞癌治疗提供基础与依据。Objective：To explore the expression of EGFR,MTDH,and ERCC1 in special subtypes of oral squamous cell carcinoma.Methods：Immunohistochemistry polymer was applied to detect special subtypes of oral squamous cell carcinoma.Results：The expression of EGFR in oral adenosquamous carcinoma was higher than that of basaloid squamous cell carcinoma,papillary squamous cell carcinoma,and spindle cell carcinoma,and the expression in verrucous carcinoma was the weakest（P〈0.05）.The expressions of MTDH and ERCC1 in oral adenosquamous carcinoma were higher than those of basaloid squamous cell carcinoma,papillary squamous cell carcinoma,and verrucous carcinoma,and the expressions in spindle cell carcinoma was the weakest（P〈0.05）.The metastasis rate of lymph nodes in oral adenosquamous carcinoma was higher than that of basaloid squamous cell carcinoma,and the rates in papillary squamous cell carcinoma,spindle cell carcinoma,and verrucous carcinoma were weaker（P〈0.05）.Conclusion：The levels of EGFR,MTDH,and ERCC1 can be used as important biomarkers for evaluation,which may provide the basis for the treatments of special subtypes of oral squamous cell carcinoma.

关 键 词：口腔鳞状细胞癌 特殊亚型 ERCC1 MTDH EGFR 

分 类 号：R739.8[医药卫生—肿瘤]