地中海贫血孕妇产前诊断中绒毛及羊水穿刺术的应用研究  

Application of villus and amniocentesis in prenatal diagnosis of thalassemia pregnant women

作　　者：王蒙 李欣 焦艳[1] WANG Men;;LI Xin;JIAO Yan(Xuzhou City Center Hospital, Xuzhou, Jiangsu 221000)

机构地区：[1]徐州市中心医院,江苏徐州221000

出　　处：《中国优生与遗传杂志》2018年第6期74-75,77,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的研究绒毛及羊水穿刺术运用在地中海贫血孕妇产前诊断中的应用及临床效果。方法选择2014年2月-2015年3月期间我院产前咨询、门诊就诊的早孕单胎孕妇且夫妇双方均为同型地中海贫血基因携带者50例为观察组,行经腹绒毛活检,并且再选择同时期就诊的50例中孕单胎孕妇且夫妇双方均为同型地中海贫血基因携带者为对照组,行羊水穿刺术,对两组的妊娠丢失率、术后并发症发生率、手术时间以及手术成功率进行比较分析。结果两组均顺利完成检查,与对照组相比,观察组的穿刺孕周短,组间比较差异明显(P<0.05),但是两组的穿刺时间对比无区别(P>0.05);相比较对照组而言,观察组的并发症发生率较低,组间比较差异显著(P<0.05);同时,两组的穿刺失败率和胎儿丢失率对比无统计学意义(P>0.05)。结论将绒毛活检术运用在地中海贫血孕妇的临床诊断中具有并发症少、诊断时间早等优点,是可靠且安全的一种产前诊断技术。Objective：To study the application and clinical effect of villus and amniocentesis in prenatal diagnosis of thalassemia pregnant women. Methods：50 cases of pregnant singleton pregnant women and couples are the same type of thalassemia gene carriers in the prenatal counseling,outpatient treatment from February 2014 to March 2015 were selected as the observation,and given the abdominal villus biopsy,and another 50 cases of regnant singleton pregnant women and couples are the same type of thalassemia gene carriers treated in the hospital at the same time were selected as the control group and were given amniocentesis. The pregnancy loss rates,postoperative complication rates,operation time and operation success rates in these two groups were compared and analyzed. Results：Both the two groups were successfully completed the surgery,and compared with the control group,the puncture gestational age in the observation group was shorter,with significant difference（P〈0.05）,but there was no difference between the puncture time（P〉0.05）;compared with the control group,the complications incidence in the observation group was lower,with significant difference between groups（P〈0.05）;what′s more,there were no significant differences between the puncture failure rates and fetal loss rates in the two groups（P〉0.05）. Conclusion：The clinical implementation of villous biopsy in the thalassemia pregnant women has the advantages of less complications,high accuracy,early diagnosis,is a reliable,safe prenatal diagnosis technology.

关 键 词：地中海贫血 产前诊断 羊水穿刺 绒毛活检 

分 类 号：R556.71[医药卫生—血液循环系统疾病]