Staurosporine targets the Hippo pathway to inhibit cell growth  

作　　者：Xueyan Ma Peixue Li Peihao Chen Jinhui Li Hongling Huang Chao Wang Wenjing Li Jianping Ding Yun Zhao Fa-Xing Yu Xiangbing Qi Lei Zhang 

机构地区：[1]State Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Shanghai Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China [2]National Institute of Biological Sciences, Beijing 102206, China [3]National Center for Protein Science Shanghai, State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 201210, China [4]School of Ufe Science and Technoloy, ShanghaiTech University, Shanghai 201210, China [5]Children's Hospital and Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China

出　　处：《Journal of Molecular Cell Biology》2018年第3期267-269,共3页分子细胞生物学报（英文版）

基　　金：This work was supported by the ＇Strategic Priority Research Program＇ of the Chinese Academy of Sciences （XDB19000000）, the National Key Research and Development Program of China （2017YFA0103601）, the National Natural Science Foundation of China （31530043 and 31625017）, the ＇Cross and Cooperation in Science and Technology Innovation Team＇ Project of the Chinese Academy of Sciences, and the CAS/SAFEA International Partnership Program for Creative Research Teams.

摘　　要：The Hippo signaling pathway was discovered to control organ size in Drosophila through regulating cell proliferation and apoptosis （Yu et al., 2015）. Arising studies over the past two decades have defined the core components and regulation mechanisms of the pathway in both Drosophila and mammals.

关 键 词：STAUROSPORINE 小径 河马 APOPTOSIS 生长 房间 指向 核心部件 

分 类 号：Q959.842[生物学—动物学] TQ463.4[化学工程—制药化工]