云南高校图书馆联盟文献共享服务平台- STAUROSPORINE

STAUROSPORINE: 作品数：48被引量：126H指数：7; 导出分析报告; 相关领域：医药卫生更多>>; 相关作者：王晓明薛绍白李源刘艳张卫卫更多>>; 相关机构：第四军医大学西京医院北京师范大学军事医学科学院华中农业大学更多>>; 相关期刊：《Chinese Medical Journal》《生理通讯》《药学学报》《天然产物研究与开发》更多>>; 相关基金：国家自然科学基金国家重点基础研究发展计划上海市自然科学基金湖北省自然科学基金更多>>

Achyranthes bidentata polypeptides prevent apoptosis by inhibiting the glutamate current in cultured hippocampal neurons被引量：7: 《Neural Regeneration Research》2020年第6期1086-1093,共8页Rong-Lu Pan Wen-Qing Hu Jie Pan Li Huang Cheng-Cheng Luan Hong-Mei Shen; supported by the National Natural Science Foundation of China,No.81073079(to HMS);the Natural Science Foundation of the Jiangsu Higher Education Institute of China,No.18KJA180009(to HMS);the Science Foundation of Nantong City of China,No.MS12018043(to HMS); Glutamate-induced excitotoxicity plays a critical role in the neurological impairment caused by middle cerebral artery occlusion.Achyranthes bidentata polypeptides have been shown to protect against neurological funct...; 关键词：Achyranthes bidentata POLYPEPTIDES APOPTOSIS caspase-3 EXCITOTOXICITY GLUTAMATE receptors MITOCHONDRIAL dysfunction MITOCHONDRIAL membrane potential neuroprotection reactive oxygen species STAUROSPORINE

Important role of a LAL regulator Sta R in the staurosporine biosynthesis and high-production of Streptomyces fradiae CGMCC 4.576被引量：8: 《Science China(Life Sciences)》2019年第12期1638-1654,共17页Hanye Guan Yue Li Jiazhen Zheng Ning Liu Jihui Zhang Huarong Tan; supported by the National Natural Science Foundation of China (31800029 and 31771378);Beijing Natural Science Foundation (5184034);the National Key Research and Development Program of China (2018YFA0901904); Staurosporine, belonging to indolocarbazole compounds, is regarded as an excellent lead compound for synthesizing antitumor agents as a potent inhibitor against various protein kinases. In this study, two separate clu...; 关键词：transcriptional regulation lead compound ANTIBIOTICS ANTITUMOR gene cluster

Anticancer potential of metabolic compounds from marine actinomycetes isolated from Lagos Lagoon sediment被引量：4: 《Journal of Pharmaceutical Analysis》2019年第3期201-208,共8页Olabisi Flora Davies-Bolorunduro Isaac Adeyemi Adeleye Moshood Olushola Akinleye Peng George Wang; supported by the University of Lagos Central Research Committee Grant (Grant No: ULCRC 2012/08); Thirty-two actinomycetes strains were isolated from sediment samples from 12 different sites at Lagos Lagoon and identified using standard physiological and biochemical procedures as well as 16S rDNA gene sequence ana...; 关键词：STREPTOMYCES bingchenggensis ULS14 METABOLIC extracts Cytotoxicity Spectroscopy Kigamicin STAUROSPORINE

Staurosporine targets the Hippo pathway to inhibit cell growth: 《Journal of Molecular Cell Biology》2018年第3期267-269,共3页Xueyan Ma Peixue Li Peihao Chen Jinhui Li Hongling Huang Chao Wang Wenjing Li Jianping Ding Yun Zhao Fa-Xing Yu Xiangbing Qi Lei Zhang; This work was supported by the ＇Strategic Priority Research Program＇ of the Chinese Academy of Sciences （XDB19000000）, the National Key Research and Development Program of China （2017YFA0103601）, the National Natural Science Foundation of China （31530043 and 31625017）, the ＇Cross and Cooperation in Science and Technology Innovation Team＇ Project of the Chinese Academy of Sciences, and the CAS/SAFEA International Partnership Program for Creative Research Teams.; The Hippo signaling pathway was discovered to control organ size in Drosophila through regulating cell proliferation and apoptosis （Yu et al., 2015）. Arising studies over the past two decades have defined the core c...; 关键词：STAUROSPORINE 小径河马 APOPTOSIS 生长房间指向核心部件

Ginkgolide B protects human umbilical vein endothelial cells against xenobiotic injuries via PXR activation被引量：6: 《Acta Pharmacologica Sinica》2016年第2期177-186,共10页Tao ZHOU Wen-ting YOU Zeng-chun MA Qian-de LIANG Hong-ling TAN Cheng-rong XIAO Xiang-lin TANG Bo-li ZHANG Yu-guang WANG Yue GAO; Aim： Pregnane X receptor （PXR） is a nuclear receptor that regulates a number of genes encoding drug metabolism enzymes and transporters and plays a key role in xeno- and endobiotic detoxification. Ginkgolide B has ...; 关键词：ginkgolide B PXR CYP3A4 MDR1 SULFORAPHANE doxorubicin STAUROSPORINE apoptosis VCAM-1 E-SELECTIN HUVECS THP-1 cells

Probe Staurosporine Drug Binding Site on Protein Kinase by PFSC: 《Chemical Research in Chinese Universities》2014年第4期644-649,共6页ZHENG Kun YANG Hong ZHAO Xiaofei JIANG Yang SUN Chuantao YANG Jia'an; Supported by the National Natural Science Foundation of China（Nos.20771030, 20671025）.Acknowledgements We are thankful to HAN Weiwei and WANG Ye in the Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, Jilin University for assistance in using the computational facilities.; We used a new approach,protein folding shape code（PFSC）,to predict the potential staurosporine binding sites in protein kinases.Firstly,all available three dimensioned（3D） structures of protein kinases in protein ...; 关键词：STAUROSPORINE Adenosine triphosphate（ATP）-binding site Protein fold shape code（PFSC） Protein folding structural alignment（PFSA） Protein databank（PDB）

Staurosporine-Induced Cell Death in Trypanosoma brucei and the Role of Endonuclease G during Apoptosis: 《Open Journal of Apoptosis》2014年第2期16-31,共16页Torsten Barth Gustavo Bruges Andreas Meiwes Stefan Mogk Celestin N.Mudogo Michael Duszenko; Apoptosis in single-cell organisms like Trypanosoma or Leishmania was characterized in several studies in the last few years [1]-[4]. Cell death in these caspase lacking protozoa is still poorly understood and a concl...; 关键词：Trypanosoma brucei ENDONUCLEASE EndoG STAUROSPORINE Programmed Cell Death APOPTOSIS

鞘内注射Staurosporine对骨癌痛大鼠脊髓小胶质细胞活化的影响被引量：5: 《临床麻醉学杂志》2013年第12期1214-1217,共4页陈勇杜晓红应俊童希忠梁应平胡衍辉徐国海; 目的观察鞘内注射蛋白激酶C（PKC）抑制剂Staurosporine对胫骨骨癌痛大鼠机械痛行为和脊髓小胶质细胞活化的影响。方法健康成年雄性SD大鼠120只，200-250g，采用随机数字表法分为五组，每组24只。除C组外，其他四组均制备胫骨骨癌痛模...; 关键词：蛋白激酶C抑制剂骨肿瘤小神经胶质细胞

Staurosporine诱导维A酸耐药早幼粒细胞白血病细胞株分化的研究被引量：1: 《诊断学理论与实践》2013年第6期614-617,共4页盖东征盛燕蔡循; 上海市自然科学基金项目(13ZR1425400); 目的:研究蛋白激酶C抑制剂staurosporine对全反式维A酸(ATRA)耐药的急性早幼粒细胞白血病(APL)细胞株的诱导分化作用及其可能的机制。方法:以ATRA耐药的APL细胞株NB4-R1为模型,通过检测细胞表面分化抗原CD11b,并进行四唑氮蓝(NBT)还原...; 关键词：蛋白激酶C 细胞分化全反式维A酸

Staurosporine对甲状腺癌SW579细胞的促凋亡作用被引量：1: 《武警后勤学院学报（医学版）》2013年第8期669-671,F0003,共4页高堃李丹; 【目的】研究星形孢菌素促进人甲状腺癌细胞SW579凋亡的作用,从而为肿瘤治疗寻找新的方向。【方法】MTT法检测ST对SW579细胞增殖的抑制作用。流式细胞术检测细胞周期分布及细胞凋亡情况。用Hochest33258及MDC染色方法分别检测细胞的凋...; 关键词：星形孢菌素甲状腺癌细胞凋亡

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