Observation of changes in the number of myocardial capillaries in rabbits after treatment of acute myocardial infarction by Tongxinluo superfine powder  

作　　者：Wu Haotian Zhang Fengshun Liu Jinyi Li Xuezhao Guo Fei Wu Yiling 

机构地区：[1]School of Basic Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing 210029, China [2]Pharmaceutical Research Institute of Yiling, Shijia-zhuang 050035, China [3]Key Laboratory of State of Traditional Chinese Medicine (Cardo-Cerebral Vessel Collateral Disease), the Traditional Research Room of Traditional Chinese Medicine, Shijiazhuang 050000, China [4]Key Disciplines of State Administration of Traditional Chinese Medicine for Collateral Disease, Shiiiazhuang 050000, China [5]Hebei University Health Science Center, pathology Laboratory, Baoding 071000, China

出　　处：《Journal of Traditional Chinese Medicine》2018年第3期406-411,共6页中医杂志（英文版）

摘　　要：OBJECTIVE: To investigate the effects of Tongxinluo superfine powder on cardiac function, infarct size and the number of myocardial capillaries in a rabbit model of acute myocardial infarction.METHODS: A total of 32 New Zealand white rabbits were randomly divided into four groups: sham operation group, model group, treatment group,and pre-treatment, the experiment of pre-treatment group was performed 6 weeks early than the treat) group,The four groups use a unified modeling technique. An acute myocardial infarction model was established through external application of70% ferric chloride on the coronary artery. After 7 d,electrocardiogram, ultrasonography of cardiac function, micro-computed tomography, pathology and other data were collected.RESULTS: In the treatment and pre-treatment groups, ejection fraction, left ventricular short axis shortening rate, left ventricular end-systolic diameter and cardiac output significantly improved, the number of capillaries significantly increased, and infarct size significantly decreased. In addition, the results suggest that the value of intra-ventricular pressure and the situation of electrocardiogram also changed to different degrees with the increasing of treatment of cycle.CONCLUSION: Tongxinluo superfine powder can protect the myocardium, improve the blood supply of the myocardium and reduce the degree of myocardial injury, during acute stage of myocardial infarction.OBJECTIVE: To investigate the effects of Tongxinluo superfine powder on cardiac function, infarct size and the number of myocardial capillaries in a rabbit model of acute myocardial infarction.METHODS: A total of 32 New Zealand white rabbits were randomly divided into four groups: sham operation group, model group, treatment group,and pre-treatment, the experiment of pre-treatment group was performed 6 weeks early than the treat) group,The four groups use a unified modeling technique. An acute myocardial infarction model was established through external application of70% ferric chloride on the coronary artery. After 7 d,electrocardiogram, ultrasonography of cardiac function, micro-computed tomography, pathology and other data were collected.RESULTS: In the treatment and pre-treatment groups, ejection fraction, left ventricular short axis shortening rate, left ventricular end-systolic diameter and cardiac output significantly improved, the number of capillaries significantly increased, and infarct size significantly decreased. In addition, the results suggest that the value of intra-ventricular pressure and the situation of electrocardiogram also changed to different degrees with the increasing of treatment of cycle.CONCLUSION: Tongxinluo superfine powder can protect the myocardium, improve the blood supply of the myocardium and reduce the degree of myocardial injury, during acute stage of myocardial infarction.

关 键 词：MYOCARDIAL INFARCTION MYOCARDIUM Mi-crocirculation X-Ray Microtomography Ferric chlo-ride TONGXINLUO superfine powder 

分 类 号：R285.5[医药卫生—中药学]