籽瓜浓缩汁的降血糖及降血脂活性研究  

Study on Hypoglycemic and Hypolipidemic Activity of Seed Watermelon Juice Concentrate

作　　者：马乐萍 田丽萍[1] 张义晖 王金辉[1] 薛琳[2] MALe-ping;TIANLi-ping;ZHANGYi-hui;WANGJin-hui;XUE Lin(Pharmacy School,Shihezi University,Shihezi 832000,Xinjiang,China;Shihezi Vegetable ResearchInstitute,Shihezi 832000,Xinjiang,China)

机构地区：[1]石河子大学药学院,新疆石河子832000 [2]石河子蔬菜研究所,新疆石河子832000

出　　处：《食品研究与开发》2018年第12期177-182,共6页Food Research and Development

基　　金：兵团科技型中小企业创新基金计划(2016AE006)

摘　　要：通过建立高血糖高血脂小鼠模型,研究籽瓜浓缩汁的降血糖及降血脂活性。利用四氧嘧啶,链脲佐菌素建立高血糖高血脂小鼠模型,记录小鼠体重,分别测定高血糖小鼠模型的血糖值,糖耐量和高血脂小鼠模型的总胆固醇和甘油三酯含量,并研究对高血脂小鼠肝脏的影响。结果表明籽瓜浓缩汁对正常小鼠的血糖血脂无影响,与模型组相比,籽瓜浓缩汁中,低剂量组的降血糖及降血脂效果优于高剂量组,改善糖耐量,并降低高血脂小鼠的血脂水平,同时对肝脏细胞还具有一定的保护作用。The hypoglycemic and hypolipidemic activities of seed watermelon juice concentrate were studied by establishing a model of hyperglycemia and hyperlipemia in mice. The model of hyperglycemia and hyperlipidemia was established by alloxan and streptozotocin. The body weight of the hyperglycemia mice model was recorded,both the blood glucose level and glucose tolerance were measured;at the same time,the total cholesterol and triglyceride content of hyperlipemia mice model were determined respectively. The effects on the liver of hyperlipidemic mice were also studied.The results showed that the watermelon juice concentrate had no effect on blood glucose and blood lipids in normal mice. Compared with the model group,the hypoglycemic and hypolipidemic effects of medium-dose and low-dose groups were better than high-dose group,improving glucose tolerance and reducing hyperlipidemia lipid levels in mice,in the meantime it has certain protective effect on liver cells.

关 键 词：籽瓜浓缩汁 系统药理学 降血糖 降血脂 

分 类 号：R285.5[医药卫生—中药学]