基于语义关系发现的阿尔茨海默病药物重定位  

Relocation of Alzheimer's Disease Drugs That Is Discovered Based on Semantic Relation

作　　者：薛均[1] 施维[1] 潘璀然 王青华 王理[1] 蒋葵[1] 董建成[1] XUE Jun;SHI Wei;PAN Cui-ran;FANG Qing-hua;FANG Li;JIANG Kui;DONG Jian-cheng(Department of Medical Informatics of Medical School,Nantong University,Nantong 226001,China)

机构地区：[1]南通大学医学院医学信息学系,南通226001

出　　处：《医学信息学杂志》2018年第4期69-73,共5页Journal of Medical Informatics

基　　金：国家自然科学基金项目"糖尿病信息管理系统中视网膜图像互操作与CAD-SR研究"(项目编号:81501559);国家自然基金项目"电子健康档案系统中临床医生信息的集成与可视化研究"(项目编号:81701793);江苏省研究生科研与实践创新计划项目"中文电子病历命名实体识别"(项目编号:KYCX17-1932)

摘　　要：针对阿尔茨海默病,提出基于语义关系SCP算法发现重定位药物的方法,从总体流程、语义关系集抽取等方面阐述算法原理,介绍结果验证方法并比较该算法与LTC-AMW算法筛选药物-AD关系对排序结果。Aiming at Alzheimer＇s disease, the paper puts forward the method of relocating drugs, which is discovered based on semantic relation SCP algorithm; it expounds on the algorithm principle from aspects like overall process and semantic relation set extraction,introduces result verification method and compares the drugs screened through the algorithm and LTC-AMW algorithm, the heapsort result of AD relation.

关 键 词：药物重定位 语义关系 SemMedDB 阿尔茨海默病 

分 类 号：R-056[医药卫生]