TET1和5hmC在上皮性卵巢癌组织中的表达及临床意义  

Expression and clinical significance of TET1 and 5hmC in epithelial ovarian cancer tissues

作　　者：赖允丽[1] 张钦乐 易升[1] 陈璞琳 蒋丽[3] 陈筠[1] 许富本 覃再隆 马刚[3] LAI Yun-li;ZHANG Qin-le;YI Sheng;CHEN Pu-lin;JIANG Li;CHEN Yun;XU Fu-ben;QIN Zai-long;MA Gang(Genetic and Metabolic Laboratory,Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region,Nanning 530000,China;Department of Obstetrics and Gynecology,Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region,Nanning 530000,China;Department of Pathology,Affiliated Tumor Hospital of Guangxi Medical University,Nanning 530021,China)

机构地区：[1]广西壮族自治区妇幼保健院遗传代谢中心实验室,南宁530000 [2]广西医科大学附属肿瘤医院病理科,南宁530021 [3]广西壮族自治区妇幼保健院妇产科,南宁530000

出　　处：《中国肿瘤临床与康复》2018年第7期790-793,共4页Chinese Journal of Clinical Oncology and Rehabilitation

基　　金：国家自然科学基金(81660460);广西自然科学基金(2015GXNSFAA139124)

摘　　要：目的探讨TET1和5hm C在浆液上皮性卵巢癌组织中的表达及其与临床病理特点的关系。方法选取2016年02月至2017年02月间广西医科大学肿瘤医院收治的59例卵巢浆液上皮性组织样本,其中,浆液性囊腺癌组织30例,交界性浆液性囊腺瘤组织7例,浆液性囊腺瘤组织12例,并选取正常卵巢组织10例作为对照。采用免疫组化法观察TET1和5hm C蛋白的表达,采用Fisher和Spearman检验法进行相关性分析。结果与对照组相比,TET1和5hm C在囊腺癌组织中的表达升高最显著,差异均有统计学意义(均P<0.05)。在囊腺癌组织中,TET1在有淋巴结转移、病理学Ⅲ期和组织学高级别中的表达均高于无淋巴结转移、病理学Ⅰ~Ⅱ期和组织学低级别,差异均有统计学意义(均P<0.05)。结论 TET1和5hm C在浆液上皮性卵巢癌组织中高表达,TET1高表达与伴有淋巴结转移、病理学晚期和高组织学级别有关。Objective To explore the expression levels of TET1 and 5 hm C in serous epithelial ovarian cancer tissues and the relationship with clinicopathological characteristics. Methods From February 2016 to February 2017,59 specimens of epithelial ovarian cancer were selected from patients treated at Guangxi Medical University with 30 specimens of serous cystadenocarcinoma,7 specimens of borderline serous cystadenoma,and 12 specimens of serous cystadenoma. The expression of TET1,5 hm C were observed by using immunohistochemical method. Fisher＇s exact test and spearman＇s test were used for statistical analysis. Results Compared with the control group,the expression levels of TET1 and 5 hm C were highest in serous ovarian cancer tissues（ all P〈0. 05）. High levels of TET1 were seen in lymphatic metastasis,pathology Ⅲ period and advanced histology groups in serous ovarian cancer tissues（ all P〈0. 05）.Conclusion The expression of TET1,5 hm C were high in serous epithelial ovarian cancer tissues. The high expression of TET1 was associated with lymphatic metastasis,pathology Ⅲ period and advanced histology.

关 键 词：TET1 5hmC 浆液上皮性卵巢肿瘤 临床病理特征 

分 类 号：R737.31[医药卫生—肿瘤]