浅谈临床生物信息学在临床医学教育中的作用及初步实践  

The role and practice of clinical bioinformatics in medical education

作　　者：张皓旻 杨波[2] 郭斌 于睿莉[3] 迟小华 陈红飞 席义博 陈锡勐 贺培凤 卢学春 ZHANG Haomin;YANG Bo;GUO Bin;YU Ruili;CHI Xiaohua;CHEN Hongfei;XI Yibo;CHEN Xirneng;HE Peifeng;LU Xuechun(Management School,Shanxi Medical University,Taiyuan Shanxi 030002,China;Department ol Hematology,Nanlou Division,National Clinical Research Center lor Geriatric Diseases,Chinese PLA General Hospital,Beijing 100853,China;Department ol Allergy,Beijing Shijitan Hospital Affiliated to Capital Medical University,Beijing 100038,China;Department ol Pharmacy,Chinese PLA Rocket Force General Hospital,Beijing 100800,China)

机构地区：[1]山西医科大学管理学院,山西太原030002 [2]中国人民解放军总医院南楼血液科,国家老年疾病临床医学研究中心,北京100853 [3]首都医科大学附属北京世纪坛医院变态反应科,北京100038 [4]中国人民解放军火箭军总医院药剂科,北京100800

出　　处：《转化医学杂志》2018年第3期175-178,共4页Translational Medicine Journal

基　　金：国家自然科学基金面上项目(81273597,81302801);解放军总医院临床科研扶持项目(2016FC-ZHCG-1004);北京市科委首都临床特色重点课题(Z161100000516006)

摘　　要：生物信息学是一门整合计算机科学及生命科学的交叉学科,已有30余年历史,但仍方兴未艾。21世纪以来,生物医学已逐渐进入大数据时代,海量的以测序为代表的基因组、转录组、蛋白质组数据将为深刻揭示人类疾病发生机制及寻找治疗药物提供了前所未有的契机。目前,在临床医学研究及教学中,生物信息学方法及应用尚未得到足够重视。作者结合临床生物信息学发展现状及未来趋势,探讨了临床生物信息学学科在临床医学教学及转化研究中的作用。Bioinformatics is an interdisciplinary subject integrating computer science and life science. It has been more than 30 years old,but it is still in the ascendant. Since the 21 th century,biomedicine has gradually entered the era of big data,massive sequencing as a representative of the genome,proteomic data will reveal human disease mechanism and provide an opportunity for hitherto unknown drugs. At present,the methods and applications of bioinformatics have not been paid enough attention in clinical research and teaching. Based on the current status and future trends of clinical bioinformatics,this paper discusses the role of clinical bioinformatics in clinical medicine teaching and translational research.

关 键 词：临床生物信息学 医学教育 基因组学 数据库 

分 类 号：R-42[医药卫生]