复配卡拉胶的流变学性质研究  

Rheological properties of compound carrageenan

作　　者：王文亚[1] 杨白雪[1] 宫艳畅 胡贝贝[1] 赵雪莉 李三鸣[1] WANG Wen-ya;YANG Bai-xue;GONG Yan-chang;HU Bei-bei;ZHAO Xue-li;LI San-ming(School of Pharmacy,Shenyang Pharmaceutical University,Benxi 117004,China)

机构地区：[1]沈阳药科大学药学院,辽宁本溪117004

出　　处：《药学学报》2018年第8期1377-1382,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81273445;81473161);国家科技重大专项资助项目(2017ZX09101001-006-012)

摘　　要：以黏度为指标考察κ-卡拉胶(kappa carrageenan,KC)-魔芋胶(konjac gum,KGM)等6种复配KC的流变学性质。采用旋转法测定黏度;通过幂律方程(power-law equation)对流变曲线进行拟合,确定流体流型;以黏度对数对浓度拟合,考察复配胶浓度对黏度的影响;根据阿伦尼乌斯(Arrhenius)方程,计算复配胶的黏流活化能(E_η),考察温度与黏度的关系;通过测定复配胶和单体胶的黏度,考察两者之间的相互作用。结果表明:6种复配胶均为假塑性流体;不同复配胶性质差异较大,KC-黄原胶(xanthan gum,XG)剪切稀化最明显,假塑性程度最强,Eη值最小,黏度热稳定性最好;KC-透明质酸钠(sodium hyaluronate,HA-Na)黏度对浓度的依赖性最强;复配胶黏度均大于单体胶的黏度之和,KC与6种辅料均具有协同增黏作用。The rheological properties of six compound gels that consists of kappa carrageenan（KC） and another excipient such as konjac gum were explored through comparison of their viscosity measured by the rotation method.The gel fluid type was dependent on the rheological curve fitted by the power-law equation.The effect of concentration on the viscosity of different compound gels was investigated by establishing the linear equation between their viscosity and concentration,the slope of which was used to determine the relation between viscosity and concentration of different compound gels.The viscous flow activation energy（Eη） was calculated by the Arrhenius equation,which was able to investigate the effect of temperature on their viscosity.The interaction between monomer and compound gels was also studied by measuring their viscosity.The results showed that six compound gels were pseudoplastic fluid.Among all compound gels,the KC-xanthan gum（KC-XG） solution exhibited the most obvious shear thinning,the strongest pseudoplasticity,while the smallest Eη,resulting in the best thermal stability of viscosity.Furthermore,the concentration of KC-sodium hyaluronate（KC-HA-Na） solution affected its viscosity significantly.The viscosity of six compound gels was greater than the summation of the two kinds of monomer gels,which suggests that there is a synergistic-viscosity interaction between KC and another excipient.

关 键 词：Κ-卡拉胶 辅料 复配胶 黏度 流变学性质 

分 类 号：R943[医药卫生—药剂学]