深共熔溶剂法合成喹啉衍生物  

Synthesis of Quinoline Derivatives by Deep Eutectic Solvent Method

作　　者：卢粤 梁萌 姜国芳[1] 谢宗波[1] 乐长高[1] LU Yue;LIANG Meng;JIANG Guo-fang;XIE Zong-bo;LE Zhang-gao(Department of Applied Chemistty,East China University of Technology,Nanehang 330013,Jiangxi,China)

机构地区：[1]东华理工大学应用化学系

出　　处：《精细化工》2018年第8期1427-1431,共5页Fine Chemicals

基　　金：国家自然科学基金(21462001,21465002);江西省自然科学基金(20142BAB203008);江西省教育厅科技项目(KJLD12006,GJJ14466,KJLD14050)

摘　　要：以2-氨基芳基酮与α-亚甲基酮为原料,在氯化胆碱/草酸组成的深共熔溶剂中,通过Friedl？nder缩合反应,合成了一系列喹啉衍生物（Ⅲa^k）,对其结构进行了1HNMR、13CNMR及HRMS表征,并对反应条件进行了优化。结果表明：在80℃、无催化剂条件下油浴加热反应1 h时收率最高,为62%~94%,深共熔溶剂重复利用3次性能无明显降低。A series of quinoline derivatives（Ⅲa^k） were synthesized in deep eutectic solvent composed of choline chloride and oxalic acid by the Friedl？nder condensation reaction using 2-aminoaryl ketones and α-methylene ketones as materials. The products were characterized by 1 HNMR, 13 CNMR and HRMS. In addition, the reaction conditions were optimized. The results indicated that a method for the synthesis of products under catalyst-free condition was developed, and the highest yields of products ranged from 62% to 94% at 80 ℃ for 1 h. The properties of deep eutectic solvent showed no obvious change after being recycled three times.

关 键 词：深共熔溶剂 氯化胆碱 Friedlander缩合反应 喹啉衍生物 精细化工中间体 

分 类 号：TQ314[化学工程—高聚物工业]