益生元对2型糖尿病患者血糖控制和血脂代谢效果的影响  

Effect of Prebiotic on the Blood Glucose Control and Lipid Metabolism of Patients with Type 2 Diabetes

作　　者：王盼 邹爱标 徐亥 游海军 孔苹苹 汪荣 彭淑珍 游静文 张炎生 夏卉琴 WANG Pan;ZOU Ai-biao;XU Hai;YOU Hai-jun;KONG Ping-ping;WANG Rong;PENG Shu-zhen;YOU Jing-wen;ZHANG Yan-sheng;XIA Hui-qin(Wuhan English Biotechnology Co,Ltd,Wuhan,Hubei Province,430000 China;Institute of Life Science and Medicine of Tsinghua University Enteric Flora and Metabolic Health Center,Beijing,100084 China;Department of Endocrinology ＆ Health Management Center,Huangpi District People＇s Hospital,Wuhan,Hubei Province,430300 China;Department of Endocrinology ＆ Health Management Center,Wuhan Huangpi Hospital of TCM,Wuhan,Hubei Province,430300 China)

机构地区：[1]武汉英纽林生物科技有限公司,湖北武汉430000 [2]清华大学生命科学与医学研究院-英纽林肠道菌群与代谢健康研究中心,北京100084 [3]黄陂区人民医院内分泌科健康管理中心,湖北武汉430300 [4]武汉市黄陂中医院内分泌科健康管理中心,湖北武汉430300

出　　处：《糖尿病新世界》2018年第11期12-14,95,共4页Diabetes New World Magazine

摘　　要：目的验证菊粉型益生元对2型糖尿病患者血糖控制和血脂代谢的影响。方法选取2016年9月—2017年9月在黄陂区人民医院和中医院就诊的2型糖尿病患者588例,平均年龄为(56.19±9.83)岁,每例患者经过2个试验周期,观察期(为期4周)给予单纯药物治疗,营养干预期(为期12周)在药物治疗基础上,接受菊粉益生元营养强化干预。结果经过益生元营养强化干预后,主要疗效指标Hb A1c和次要指标FBG、2 h PG、CHOL、TRIG、LDL、BMI、BP与试验前和观察期第4周时比较显著降低,差异有统计学意义(P<0.05),HDL对比试验前差异无统计学意义,但对比观察期第4周,HDL升高,差异有统计学意义(P<0.01)。结论菊粉型益生元干预有利于2型糖尿病患者的体重、血压、血糖、血脂的控制,营养强化干预比单纯的药物治疗方式效果更佳。Objective To verify the effect of prebiotic on the blood glucose control and lipid metabolism of patients with type 2 diabetes. Methods 588 cases of patients with type 2 diabetes diagnosed in our hospital from September 2016 to September 2017 were selected,（56.19±9.83）years old on average, after two test cycles, during the observation period（four weeks）, the simple drugs were given, during the nutrition intervention period（12 weeks）, the intensive intervention of inulin prebiotic were given on the basis of the drugs. Results After the intensive intervention of prebiotic, the major curative effect indicator Hb A1 c and second indicators FBG, 2 h PG,CHOL, TRIG, LDL, BMI, BP obviously decreased compared with those before test and during the observation period, and the differences were statistically significant（P〈0.05）, and the difference in the HDL before and after test was statistically significant, but the HDL increased compared with that in the fourth week during the observation period, and the difference was statistically significant（P〈0.01）. Conclusion The inulin prebiotic intervention is conductive to controlling the weight, blood pressure, blood glucose and blood liquid of patients with type 2 diabetes, and the nutrition intensive intervention has a better effect than the simple drug treatment method.

关 键 词：菊粉 益生元 2型糖尿病 血糖 血脂 

分 类 号：R587.1[医药卫生—内分泌] R151.3[医药卫生—内科学]