Application of alkaloids in reversing multidrug resistance in human cancers  

作　　者：WANG Meng LIU Ze-Fa TANG Hua CHEN Bao-An 

机构地区：[1]Department of Hematology and Oncology,Zhongda Hospital,School of Medicine,Southeast University [2]Department of Hematology,People's Hospital of Xinghua City

出　　处：《Chinese Journal of Natural Medicines》2018年第8期561-571,共11页中国天然药物（英文版）

基　　金：supported by the National Natural Science Foundation of China(Nos.81170492 and 81370673);the Key Medical Subjects of Jiangsu Province,China(No.BL2014078);the Key Department of Jiangsu Province,China(2016-2020)

摘　　要：Multidrug resistance(MDR) in human cancer is one of greatest challenges in cancer therapy.Natural products,especially the alkaloids,exert reversed effects on MDR with low toxicity,by interacting with various targets.In this review article,we summarize the recent progress made in the research of the main alkaloids,including classification,function,mechanism,research status,and application in reversing MDR.Multidrug resistance（MDR） in human cancer is one of greatest challenges in cancer therapy.Natural products,especially the alkaloids,exert reversed effects on MDR with low toxicity,by interacting with various targets.In this review article,we summarize the recent progress made in the research of the main alkaloids,including classification,function,mechanism,research status,and application in reversing MDR.

关 键 词：MULTIDRUG RESISTANCE ALKALOIDS CANCER 

分 类 号：R965[医药卫生—药理学]