三阴乳腺癌P53突变热点及与预后的关系  

P53 Hot Spots Mutation in Triple Negative Breast Cancer and its Relationship with Prognosis

作　　者：敖睿[1] 朱学强[1] 刘浩[1] 蔡丽君 杨柳 A;ZHUXue-qiang;LIU Hao;CAILi-jun;YANG Liu(Department of Oncology,Sichuan Provincial People＇s Hospital,Chengdu,Sichuan,610072,China)

机构地区：[1]四川省人民医院肿瘤科,四川成都610072

出　　处：《现代生物医学进展》2018年第15期2906-2909,共4页Progress in Modern Biomedicine

摘　　要：目的:探讨三阴乳腺癌(TNBC)P53基因热点突变的情况及其与预后的关系。方法:选取2007年1月至2010年12月四川省人民医院收治的71例TNBC患者作为研究对象,采用免疫组化法检测71例TNBC患者手术石蜡标本的P53蛋白表达情况,采用ADx-ARMS方法检测P53基因突变热点情况,并分析两者与TNBC复发转移的关系。结果:71例患者总共有14例出现复发或转移,复发或转移发生率为19.7%。71例患者P53蛋白阳性表达率为69.0%,P53蛋白表达阳性患者的复发或转移率为18.4%,与P53蛋白表达阴性患者的复发或转移率22.7%比较,差异无统计学意义(P>0.05)。总共有5例患者检出P53热点突变,P53热点突发生率为7.0%。P53热点突变全部都在P53蛋白阳性表达的患者中检出,而有P53热点突变的患者均没有出现复发或转移。结论:P53热点突变在TNBC患者中发生率不高,均出现在有P53蛋白阳性表达的患者中,而出现P53热点突变的患者预后较好。Objective： To detect P53 hot spots mutation in triple negative breast cancer（TNBC） and explore the relationship between P53 hot spots mutation and prognosis of TNBC. Methods： A total of 71 patients with TNBC, who were treated in Sichuan Provincial People＇s Hospital from January 2007 to December 2010, were chosen as subjects. The expression of P53 protein in paraffin specimens of 71 patients with TNBC was detected by immunohistochemistry; the hot spot of P53 gene mutation was detected by ADx-ARMS method, and the relationship between the two factors and recurrence and metastasis of TNBC was analyzed. Results： Among the 71 patients, there wee 14 patients with recurrence or metastasis, the incidence of recurrence or metastasis was 19.7%; the positive rate of P53 protein in 71 patients was 69.0%, the rate of recurrence or metastasis in P53 positive patients was 18.4%, the rate of recurrence or metastasis in patients with negative P53 protein expression was 22.7%, and the difference was not statistically significant（P〉0.05）. P53 hotspot mutations of 5 patients were detected, the incidence of P53 hotspots was 7.0%. The P53 hotspot mutations were all detected in patients with positive P53 protein expression, none of the patients with P53 hotspot mutations showed recurrence or metastasis. Conclusion： P53 hot spots mutation has a low incidence in the patients with TNBC, which appears in the patients with positive expression of P53 protein.The prognosis of patients with P53 hotspot mutation is better.

关 键 词：三阴乳腺癌 P53 突变 预后 

分 类 号：R737.9[医药卫生—肿瘤]