α-磺酰胺芳基酰胺化合物的合成研究  

Facile Synthesis and Research of α-Sulfonamides Aryl Amides

作　　者：李飞龙[1] 胡雅雯 王玉麟[1] 赵敏[1] 陈建中[2] LI Fei-long;HU Ya-wen;WANG Yu-lin;ZHAO Min(School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shang-hai 200237,China;School of Chemistry and Chemical Engineering,Shanghai Jiao Tong University,Shanghai 200240,China)

机构地区：[1]华东理工大学化学与分子工程学院,上海200237 [2]上海交通大学化学化工学院,上海200240

出　　处：《化学试剂》2018年第9期823-830,共8页Chemical Reagents

摘　　要：以最常见的芳基乙酮为原料,经二氧化硒氧化得到相应芳基酮酸,在氯化亚砜氯化后直接与不同的胺反应得到一系列芳基酮酰胺,接着与磺酰胺加成得到关键中间体α-磺酰亚胺芳基酰胺,最后还原得到目标产物α-磺酰胺芳基酰胺。合成路线具有原料易得、操作方便、收率较高等优点,其结构经1HNMR、13CNMR、高分辨质谱、红外和熔点等手段表征。该产物可用于生物活性物质的合成中。The aryl ketonic acid were prepared readily via oxidation reaction of substitutional acetophenones and subsequent chlorination and amination to afford the corresponding aryl keto-amides.The key intermediates α-sulfimide aryl amides were coupled with sulfamide.A series of α-sulfamide aryl amides were obtained with good yields after reduction.The structures were characterized by 1HNMR,13CNMR,HR-MS,IR and melting point measurement.The aminoamide products could subsequently be used in the synthesis of bioactive compounds.

关 键 词：α-氨基酰胺 α-磺酰胺芳基酰胺 合成 生物活性物质 

分 类 号：O625[理学—有机化学] O622.6[理学—化学]