腹腔镜直肠癌根治术对患者胃肠激素、内脏蛋白及疼痛应激的影响  

Effect of laparoscopic radical resection of rectal cancer on gastrointestinal hormones,visceral protein and pain stress in patients

作　　者：周志林[1] 梅勇[1] 戴军[1] 杨旭辉[1] 赵志辉[1] ZHOU Zhi-lin;MEI Yong;DAI Jun;YANG Xu-hui;ZHAO Zhi-hui(Department of General Surgery,Liyuan Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology,Wuhan 430077,China)

机构地区：[1]华中科技大学同济医学院附属梨园医院普通外科,湖北武汉430077

出　　处：《海南医学院学报》2018年第18期1654-1657,共4页Journal of Hainan Medical University

基　　金：湖北省自然科学基金资助项目(2009CDB117)~~

摘　　要：目的:探讨腹腔镜直肠癌根治术对患者胃肠激素、内脏蛋白及疼痛应激的影响。方法:选取于我院进行直肠癌根治术治疗的96例患者作为研究对象,随机分为观察组48例与对照组48例,观察组实施腹腔镜直肠癌根治术,对照组实施开腹直肠癌根治术,检测并比较两组患者胃泌素(GAS)、胃动素(MTL)、血管活性肠肽(VIP)、转铁蛋白(TRF)、视黄醇结合蛋白(RbP)、白蛋白(ALB)、前白蛋白(PRE)、P物质(SP)、缓激肽(BK)、前列腺素-E2(PGE_2)水平。结果:术前,两组的GAS、MTL、VIP均无统计学差异(P>0.05);术后1、3、5d,两组的GAS、MTL、VIP均比术前显著降低,差异均有统计学意义(P<0.05);观察组术后1、3、5d的GAS、MTL、VIP均高于同期对照组,差异均有统计学意义(P<0.05)。术前,两组的TRF、RbP、ALB、PRE均无统计学差异(P>0.05);术后1、3、5d,两组的TRF、RbP、ALB、PRE均比术前显著降低,差异均有统计学意义(P<0.05);观察组术后1、3、5d的TRF、RbP、ALB、PR、均高于同期对照组,差异均有统计学意义(P<0.05)。术前,两组患者的SP、BK、PGE2均无统计学差异(P>0.05);术后1、3、5d,两组患者的SP、BK、PGE2均比术前显著升高,差异均有统计学意义(P<0.05);观察组术后1、3、5d的SP、BK、PGE2均低于同期对照组,差异均有统计学意义(P<0.05)。结论:腹腔镜直肠癌根治术可帮助患者更快的恢复胃肠功能,且造成的疼痛应激更轻。Objective： To investigate the effects of laparoscopic radical resection of rectal cancer on gastrointestinal hormones, visceral protein and pain stress. Methods： From January 2017 to December 2017, 96 patients with rectal cancer radical resection were selected as the research objects, and the patients were randomly divided into the observation group （ n =48） and the control group （ n =48）. The observation group received laparoscopic radical resection of rectal cancer, while the control group underwent open radical resection of rectal cancer. The levels of gastrin （GAS）, motilin （MTL）, vasoactive intestinal peptide （VIP）, transferrin （TRF）, retinol binding protein （RbP）, albumin （ALB）, prealbumin （PRE）, P substance （SP）, bradykinin （BK）, and prostaglandin -E2 （PGE 2） were measured and compared in the two groups. Results： Before operation, there was no significant difference in GAS, MTL and VIP between the two groups （ P 〉0.05）. 1, 3, and 5 days after operation, the GAS, MTL and VIP of the two groups were significantly lower than those before operation, and the differences were statistically significant （ P 〈0.05）. 1, 3, and 5 days after operation, GAS, MTL and VIP of the observation group were higher than that of the control group at the same time, and the difference was statistically significant （ P 〈0.05）. Before operation, there was no significant difference in TRF, RbP, ALB and PRE between the two groups （ P 〉0.05）. 1, 3 and 5 days after operation, the TRF, RbP, ALB and PRE of the two groups were significantly lower than those before operation, and the differences were statistically significant （ P 〈0.05）. 1, 3 and 5 days after operation, TRF, RbP and ALB of the observation group were all higher than those in the control group at the same time, and the differences were statistically significant （ P 〈0.05）. Before operation, there was no significant difference in SP, BK and PGE 2 between the two groups （ P 〉0.05）. 1,

关 键 词：腹腔镜直肠癌根治术 胃肠激素 内脏蛋白 疼痛应激 

分 类 号：R735.37[医药卫生—肿瘤]