Pd（Ⅱ）-Catalyzed Phosphorylation of Enamido C（sp^2）-H Bonds： A General Route to β-Amido-vinylphosphonates  

作　　者：Baokun qiao Hao-qiang Cao Yin-Jun Huang Yue Zhang Jing Nie Fa-Guang Zhang Jun-An Ma 

机构地区：[1]Department of Chemistry, Tianjin Key Laboratory of Molecular Optoelectronic Sciences, and Tianjin Collaborative Innovation Center of Chemical Science & Engineering, Tianjin University, Tianjin 300072, China

出　　处：《Chinese Journal of Chemistry》2018年第9期809-814,共6页中国化学（英文版）

摘　　要：Organophosphorus compounds are essential structures in modern pharmaceutical, agrochemical, and material sciences. The development of new and efficient methods for the synthesis of C-P bonds has been an important focus of research. We herein report a Pd-catalyzed enamido C（sp2）-H phosphorylation for direct construction of C-P bonds under simple and convenient conditions without the need for additional ligands or directing groups. The present reaction can tolerate a wide range of functional groups, and furnish a variety of phosphorylation products including tetrasubstituted-vinyl β-aminophosphonates that are otherwise difficult to access. This protocol was also exemplified into the late-stage modification of bioactive natural prod- ucts and was suitable for large-scale synthesis.Organophosphorus compounds are essential structures in modern pharmaceutical, agrochemical, and material sciences. The development of new and efficient methods for the synthesis of C-P bonds has been an important focus of research. We herein report a Pd-catalyzed enamido C（sp2）-H phosphorylation for direct construction of C-P bonds under simple and convenient conditions without the need for additional ligands or directing groups. The present reaction can tolerate a wide range of functional groups, and furnish a variety of phosphorylation products including tetrasubstituted-vinyl β-aminophosphonates that are otherwise difficult to access. This protocol was also exemplified into the late-stage modification of bioactive natural prod- ucts and was suitable for large-scale synthesis.

关 键 词：C-H activation PHOSPHORYLATION palladium catalysis ENAMINES late-stage functionalization 

分 类 号：TQ44[化学工程—化学肥料工业] TP333.4[自动化与计算机技术—计算机系统结构]