PARP在视网膜疾病中的作用及机制研究  

Study on the Role and Mechanism of PARP in Retinal Diseases

作　　者：何畅 张秋丽[2] 谢飞 张天资[2] HE Chang;ZHANG Qiu-li;XIE Fei;ZHANG Tian-zi(Clinical Medical College,Inner Monglia University for Nationalities,Tongliao 028000,China;Affiliated Hospital,Inner Monglia University for Nationalities,Tongliao 028000,China)

机构地区：[1]内蒙古民族大学临床医学院,内蒙古通辽028000 [2]内蒙古民族大学附属医院,内蒙古通辽028000

出　　处：《内蒙古民族大学学报（自然科学版）》2018年第3期268-271,共4页Journal of Inner Mongolia Minzu University：Natural Sciences

基　　金：国家自然科学基金项目(81660165)

摘　　要：脱氧核糖核酸修复酶(poly ADP-ribose polymerase,PARP)是参与细胞中DNA损伤反应的核酶。目前认为PARP的激活在视网膜损伤类疾病病程发展中发挥重要作用,笔者总结近年来的相关科研成果,就视网膜疾病中PARP的作用机制进行了综述。Poly ADP-ribose polymerase（PARP）is a ribozyme which is involved in cellular DNA damage response.At present,it is believed that the activation of PARP plays an important role in the progression of retinal injury diseases. We summarize the recent related research achievements and review the action mechanism, prevention and therapy targets of PARP in retinal diseases.

关 键 词：PARP 视网膜疾病 发病机制 

分 类 号：R774.1[医药卫生—眼科]