肥厚性硬脑膜炎19例临床分析  

Clinical analysis of 19 patients with hypertrophic cranial pachymeningitis

作　　者：范道丰 陈银娟 李洵桦[2] 潘丽英 胡小红 陈衍贵 FAN Dao-feng;CHEN Yin-juan;LI Xun-hua(Department of Neurology,Longyan Frist Hospital Affiliated to Fujian Medical University,Longyan 364000,China)

机构地区：[1]福建医科大学附属龙岩第一医院神经内科,364000 [2]中山大学附属第一医院神经内科

出　　处：《临床神经病学杂志》2018年第5期372-375,共4页Journal of Clinical Neurology

摘　　要：目的探讨肥厚性硬脑膜炎(HCP)的临床特点。方法对19例HCP患者的临床资料进行回顾性分析。结果 HCP病因复杂,临床上最常见为头痛,伴或不伴颅神经损害或小脑共济失调。CSF可异常,但无明显特异性; MRI表现为肥厚的硬脑膜T1WI呈等、略低信号,T2WI呈明显低信号,增强后扫描强化明显,部分区域呈结节状强化。糖皮质激素及免疫抑制治疗有效。结论 HCP病因较复杂,临床表现以慢性头痛伴或不伴颅神经缺损为主要症状,MRI检查有特征性表现,糖皮质激素或免疫抑制剂是治疗主要药物。Objective To analyze the clinical features of hypertrophic cranial pachymeningitis （HCP）. Methods The clinical data of 19 patients with HCP were analyzed retrospectively. Results The etiology of HCP was complicated, the most common clinically was headache, with or without cranial nerve damage or cerebellar ataxia. Cerebrospinal fluid couht be abnormal, but no obvious specificity. The magnetic resonance imaging in T~ WI was equal-slightly lower, and in T2WI was obviously low signal, the thickened dura mater was markedly enhanced and part of the region was nodular enhancement through reinforced scanning, glucocortieoid and immunosuppressive therapy was effective. Conclusions The etiology of HCP is complicated. Headache with or without cranial nerve damage is the most common clinically. MRI has a charac, teristic manifestation. Glucocorticoid or immunosuppressive agents are the primary drug for treatment.

关 键 词：肥厚性硬脑膜炎 临床表现 CSF MRI 

分 类 号：R742[医药卫生—神经病学与精神病学]