Influence of polymorphisms in VEGF, ACE, TNF and GST genes on the susceptibility to retinopathy of prematurity among Chinese infants  

作　　者：Xiao-Jun Lei Yong-Xia Zhao Tong Qiao 

机构地区：[1]Department of Ophthalmology,Friendship Hospital of Dalian [2]Department of Ophthalmology,Center Hospital in Cangzhou [3]Department of Ophthalmology,Shanghai Children's Hospital,Shanghai Jiao Tong University

出　　处：《International Journal of Ophthalmology(English edition)》2018年第9期1451-1457,共7页国际眼科杂志（英文版）

摘　　要：AIM： To investigate common polymorphisms in VEGF, ACE, TNF and GST genes with retinopathy of prematurity（ROP） risk among Chinese infants. METHODS： Nine polymorphisms in the above genes were genotyped on 724 advanced cases of ROP and 878 prematurely-born infants of low birth weight who were without any ophthalmologic disease. The frequencies of the polymorphisms were compared between cases and controls to identify the association present, if any. RESULTS： Of the nine polymorphisms, only two showed significant associations： ACE insertion deletion（ID） polymorphism（P=0.031） and TNF-308 G/A polymorphism（P〈0.001）. The former was associated with a reduced ROP risk [ID genotype, adjusted OR（aOR）： 0.603, 95%CI： 0.427-0.893, P=0.034; DD genotype, aOR： 0.468, 95%CI： 0.229-0.626, P=0.002], while the latter showed an increased risk（GA genotype, aOR： 1.956, 95%CI： 1.396-2.465, P〈0.001; AA genotype, aOR： 2.809, 95%CI： 1.802-4.484, P〈0.001）. The association was also noted at the allele level（ACE D allele a OR： 0.698, 95%CI： 0.294-0.883, P〈0.001; TNF-308A allele a OR： 1.776, 95%CI： 1.446-2.561, P〈0.001）. CONCLUSION： The ACE ID polymorphism can protect against ROP development while the TNF-308G/A can increase the risk of the disease among Chinese infants.AIM： To investigate common polymorphisms in VEGF, ACE, TNF and GST genes with retinopathy of prematurity（ROP） risk among Chinese infants. METHODS： Nine polymorphisms in the above genes were genotyped on 724 advanced cases of ROP and 878 prematurely-born infants of low birth weight who were without any ophthalmologic disease. The frequencies of the polymorphisms were compared between cases and controls to identify the association present, if any. RESULTS： Of the nine polymorphisms, only two showed significant associations： ACE insertion deletion（ID） polymorphism（P=0.031） and TNF-308 G/A polymorphism（P〈0.001）. The former was associated with a reduced ROP risk [ID genotype, adjusted OR（aOR）： 0.603, 95%CI： 0.427-0.893, P=0.034; DD genotype, aOR： 0.468, 95%CI： 0.229-0.626, P=0.002], while the latter showed an increased risk（GA genotype, aOR： 1.956, 95%CI： 1.396-2.465, P〈0.001; AA genotype, aOR： 2.809, 95%CI： 1.802-4.484, P〈0.001）. The association was also noted at the allele level（ACE D allele a OR： 0.698, 95%CI： 0.294-0.883, P〈0.001; TNF-308A allele a OR： 1.776, 95%CI： 1.446-2.561, P〈0.001）. CONCLUSION： The ACE ID polymorphism can protect against ROP development while the TNF-308G/A can increase the risk of the disease among Chinese infants.

关 键 词：inflammation oxidation POLYMORPHISMS retinopathy of prematurity VASCULARIZATION 

分 类 号：R77[医药卫生—眼科]