非小细胞肺癌患者术后复发240例临床分析  

Postoperative recurrence of non-small cell lung cancer: analysis of 240 cases

作　　者：金澄宇[1] 续文栋 杜亮[1] 陈康[1] 唐国栋 王小雷[1] JIN Cheng-yu;XU Wen-dong;DU Liang;CHEN Kang;TANG Guo-dong;WANG Xiao-lei(Department of Thoracic Surgery,People＇s Hospital of Xinjiang Uygur Autonomous Region,Urumqi,Xinjiang 830003,China)

机构地区：[1]新疆维吾尔自治区人民医院胸外科,新疆乌鲁木齐830003 [2]新疆医科大学研究生学院,新疆乌鲁木齐830054 [3]山东大学附属济南市中心医院,山东济南250013

出　　处：《中国临床研究》2018年第7期933-935,939,共4页Chinese Journal of Clinical Research

基　　金：新疆维吾尔自治区自然科学基金资助项目(2015211C193)

摘　　要：目的探讨非小细胞肺癌(NSCLC)患者手术切除后复发的影响因素。方法回顾性分析新疆维吾尔自治区人民医院2010年10月1日至2016年10月6日经手术治疗的738例NSCLC患者的临床资料。截止2016年10月6日,738例NSCLC中有240例(32.52%)患者术后复发。采用直接测序或高度敏感的聚合酶链反应(PCR)分析方法检测患者表皮生长因子受体(EGFR)是否突变。结果单因素分析显示,年龄<60岁、男性、腺癌、病理分期高是NSCLC术后复发的影响因素(P<0.01,P<0.05)。多因素分析发现,组织学类型为腺癌、病理分期高和EGFR突变状态是NSCLC术后复发的独立危险因素(P<0.01,P<0.05)。结论对于NSCLC术后患者进行EGFR突变状态的检测十分必要。Objective To explore the influencing factors of non-small cell lung cancer（ NSCLC） recurrence after surgical resection. Methods The clinical data of 738 NSCLC patients operated in People＇s Hospital of Xinjiang Uygur Autonomous Region from October 2010 to October 2016 were analyzed retrospectively. Until October 6,2016,there were 240 patients with postoperative recurrence. Direct sequencing or highly sensitive polymerase chain reaction（ PCR） analysis was used to detect the mutation of epidermal growth factor receptor（ EGFR） in patients. Results Univariate analysis showed that age 60 years,male,adenocarcinoma and high pathological stage were the influencing factors for postoperative recurrence of NSCLC（ P〈0. 01,P〈0. 05）. Multiple factor analysis showed that the histologic type of adenocarcinoma, high histopathological stage and EGFR mutation were independent risk factors for the postoperative recurrence of NSCLC（ P〈0. 01,P〈0. 05）.

关 键 词：肺癌 临床特点 手术治疗 术后复发 表皮生长因子受体 突变 

分 类 号：R734.2[医药卫生—肿瘤]