消化道癌症患者癌症家族史发生情况及分离比估算  

Study on familial cancer history status and separation ratio estimation among patients with digestive tract cancers

作　　者：刘娜[1] 王临池[1] 黄春妍[1] 陆艳[1] 黄桥梁[1] 胡一河 LIU Na;WANG Lin-chi;HUANG Chun-yan;LU Yan;HUANG Qiao-liang;HU Yi-he(Suzhou Municipal Center for Disease Control and Prevention,Jiangsu Suzhou 215004,China)

机构地区：[1]苏州市疾病预防控制中心

出　　处：《江苏预防医学》2018年第6期637-639,共3页Jiangsu Journal of Preventive Medicine

基　　金：苏州市“科教兴卫”青年科技项目(kjxw2015037);苏州市科教兴卫项目(kjxw 2016046)

摘　　要：目的 研究消化道癌症患者家族史和遗传方式。 方法 采用面对面调查的方法，对苏州市消化道癌症患者的一二三级亲属构成及其癌症患病情况进行调查，采用描述流行病学方法分析家族癌症史发生情况，Li-Mantel-Cart法估算分离比。 结果 共调查消化道癌症患者720人，病例家族癌症及消化道癌症家族史发生率分别为36.67%、28.61%，一级亲属癌症和消化道癌症患病率均高于二三级亲属（ P 值均＜0.05）；消化道癌症在同胞中分离比（95% CI ）为0.01（ 0.18～0.21）。 结论 一级亲属癌症和消化道癌症患病率显著高于二三级亲属；消化道癌症的遗传方式为多基因遗传。需对一级亲属有癌症尤其是消化道癌症史的高危家庭进行重点健康教育。Objective To study the familial cancer history and the genetic pattern of patients with digestive tract cancers. Methods Patients with digestive tract cancer in Suzhou city were investigated by face-to-face survey for the composition and cancer occurrence of all three degree relatives. The familial cancer history was described by epidemiological analysis and separation ratio was estimated by Li-Mantel-Cart method. Results A total of 720 patients with digestive tract cancers were investigated, The occurrences of familial cancer and digestive tract cancer were 36.67% and 28.61%,respectively. The prevalence rates of first degree relatives suffering from cancer and digestive tract cancer were significantly higher than those of second and third degree relatives（all P 〈0.05）. The separation ratio （95% CI ） was 0.01 （-0.18-0.21） for digestive tract cancer among siblings. Conclusion The prevalence rates of first degree relatives of cases suffering from cancer and digestive tract cancer were significantly higher than those of second and third degree relatives. The genetic pattern of digestive tract cancer was mainly multi-gene inheritance. Priority health education should be given to families with a high risk of cancer, especially digestive tract cancer.

关 键 词：消化道癌症 癌症家族史 家系调查 分离比 遗传流行病学 

分 类 号：R735[医药卫生—肿瘤]