Novel insights in the prevention of perinatal transmission of hepatitis B  

作　　者：Konstantinos Tziomalos Georgios Neokosmidis Georgios Mavromatidis Konstantinos Dinas Konstantinos Tziomalos;Georgios Neokosmidis;Georgios Mavromatidis;Konstantinos Dinas(Department of Internal Medicine, Medical Sch-ool, Aristotle University of Thessaloniki, AHEPA Hospital,Thessaloniki 54636, Greece;Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki,Hippokration Hospital, Thessaloniki 54642, Greece;Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki 54642, Greece)

机构地区：[1]Department of Internal Medicine, Medical Sch-ool, Aristotle University of Thessaloniki, AHEPA Hospital,Thessaloniki 54636, Greece [2]Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki,Hippokration Hospital, Thessaloniki 54642, Greece [3]Department of Obstetrics and Gynecology, Medical School, Aristotle University of Thessaloniki, Hippokration Hospital, Thessaloniki 54642, Greece

出　　处：《World Journal of Hepatology》2018年第11期795-798,共4页世界肝病学杂志（英文版）（电子版）

摘　　要：Perinatal transmission of hepatitis B virus （HBV） in-fection is major contributor to the growing burden of chronic hepatitis B worldwide. Administration of HBV immunoglobulin and HBV vaccination as soon after pre-gnancy as possible are the mainstay of prevention of perinatal transmission of HBV infection. In women with high viral loads, antiviral prophylaxis also appears to be useful. Lamivudine, telbivudine and tenofovir have been shown to be both safe and effective in this setting but tenofovir is the frst-line option due to its low potential for resistance and more favorable safety profle.Perinatal transmission of hepatitis B virus(HBV) infection is major contributor to the growing burden of chronic hepatitis B worldwide. Administration of HBV immunoglobulin and HBV vaccination as soon after pregnancy as possible are the mainstay of prevention of perinatal transmission of HBV infection. In women with high viral loads, antiviral prophylaxis also appears to be useful. Lamivudine, telbivudine and tenofovir have been shown to be both safe and effective in this setting but tenofovir is the first-line option due to its low potential for resistance and more favorable safety profile.

关 键 词：TENOFOVIR Perinatal transmission Hepatitis B LAMIVUDINE TELBIVUDINE 

分 类 号：R512.62[医药卫生—内科学]