One-step Construction of Xanthone Scaffold Assisted by Microwave Irradiation to Optimize the Synthesis of DMXAA  

作　　者：JIANG Zhenlei LIU Jie ZHOU Fan ZHANG Jianrun LIU Zhijun ZHANG Chao CHEN Heru 

机构地区：[1]Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, P. R. China [2]Department of Allergy, the Third Affiliated Hospital of Shenzhen University, Shenzhen 518020, P. R. China [3]Guangdong Province Key Laboratory of Pharmaeodynamie Constituents of TCM and New Drugs Research Guangzhou 510632, P. R. China

出　　处：《Chemical Research in Chinese Universities》2018年第6期918-922,共5页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China（No.81172982） and the Natural Science Fotmdation of Guangdong Province, China（No.2015A030311012）.

摘　　要：An efficient and concise synthesis of 5,6-dimethylxanthenone-4-acetic acid（DMXAA） was developed. The overall yield of this 3-step procedure was 82%. The key reaction is the one-step construction of xanthone scaffold between 2,5-dibromo-3,4-dimethylbenzoic acid and 2-hydroxyphenyl-acetic acid assisted by microwave irradiation.An efficient and concise synthesis of 5,6-dimethylxanthenone-4-acetic acid（DMXAA） was developed. The overall yield of this 3-step procedure was 82%. The key reaction is the one-step construction of xanthone scaffold between 2,5-dibromo-3,4-dimethylbenzoic acid and 2-hydroxyphenyl-acetic acid assisted by microwave irradiation.

关 键 词：5 6-Dimethylxanthenone-4-acetic acid XANTHONE Microwave irradiation ANTI-CANCER 

分 类 号：O626.31[理学—有机化学] TN015[理学—化学]