大豆磷脂对脑梗死患者红细胞脂质成分的作用  

Effects of soybean lecithin on lipid composition of erythrocyte in patients with cerebral infarction

作　　者：石富成[1] 周景春[1] 孟冬娅[1] 薜文成[1] 王耀山[1] 殷军[2] 

机构地区：[1]沈阳军区总医院,110016 [2]沈阳药科大学

出　　处：《卒中与神经疾病》2002年第4期212-214,共3页Stroke and Nervous Diseases

摘　　要：目的　寻求脑梗死患者红细胞 (RBC)膜脂质成分正常化、流动性增加的措施。方法　给 30名急性期脑梗死者在脑梗死常规治疗基础上加服大豆磷脂 10g·tid .服用 30d。观察服用大豆磷脂前后RBC和血浆脂质成分的变化 ,并与不服用大豆磷脂常规治疗的急性期脑梗死患者和正常组对比。结果　脑梗死患者服用大豆磷脂 30天 ,血浆总胆固醇下降 0 .72mmol/L ,总磷脂上升 1.4 5mmol/L ,RBC中胆固醇下降 0 .11mg/10 10 RBC、磷脂酰胆碱上升 0 .10mg/10 10 RBC、总磷脂上升 0 .14mg/10 10 RBC ,胆固醇 /总磷脂比值下降0 .0 6 ,饱和脂肪酸 /双键不饱和脂肪酸比值下降 0 .12 ,红细胞滤过指数下降 0 .0 9,RBC的脂质成分与流动性均与正常组无显著差异 (P >0 .0 5 )。Objective To normalize lipid composition of erythrocyte membrane in patients with cerebral infarction.Methods 30 patients within 48 h after the onset of cerebral infarction had the treatment with both conventional treatment and soybean lecithin 10 g three times a day/d.po. for 30 days.Results The level of total plasma cholesteral decreased by 0.69 mmol/L, the level of total phospholipids increased by 1.35 mmol/L. In red blood cell(RBC),the cholesterol content decreased by 0.11 mg/10 10 RBC, phosphatidylcholine(PC) and total phospholipids increased by 0.109 mg/10 10 RBC, and 0.135 mg/10 10 RBC, respectively; cholesterol to total phosplolipids ratio and saturated fatty acid to unsaturated fatty acid ratio decreased by 0.059 and 0.12 respectively. Erythrocyte deformability increased. The composition of RBC membrane mentioned above in patients with cerebral infarction were significantly lower than those in normal adults( P < 0.05 ) before taking soybean lecithin, but after taking soybean lecithin, these parameters were no different when compareted with those of normal adult( P > 0.05 ).Conclusion Soybean lecithin could make lipid composition of RBC in patients with cerebral infarction to normalize.

关 键 词：大豆磷脂 脑梗死 红细胞 脂质成分 

分 类 号：R743.33[医药卫生—神经病学与精神病学]