采用[^(123)I]β-CITSPECT检测帕金森病患者的神经变性与睡眠微观结构  

Sleep microstructure and neurodegeneration as measured by [ ^(123)I]β -CIT SPECT in treated patients with Parkinson’ s disease

作　　者：Happe S. Anderer P. PirkerW. 李锐 

机构地区：[1]Dept. of Clinical Neurophysiology, University of Gttingen, Robert- Koch- Str. 40, 37099 Gttingen, Germany Dr.

出　　处：《世界核心医学期刊文摘（神经病学分册）》2005年第6期27-28,共2页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Objectives Along with spindles, K- complexes are well known hallmarks of stage 2 (S2) sleep. However, little is known about their quantity in S2 sleep of patients with Parkinson’ s disease (PD). Setting Sleep laboratory, Department of Neurology, University of Vienna, Austria. Patients and methods Whole- night polysomnography (PSG) was performed in twelve treated PD patients and ten healthy controls without history of sleep complaints. The quantity of spontaneous K- complexes, K- alpha- complexes, and sleep spindles in one hour S2 sleep, distributed in four epochs of 15 minutes all through the night, were visually selected and analysed. The quantity and the temporal course of these phasic events were compared with the quantity in age- matched healthy controls. Nine of the twelve PD patients underwent [123I]β - CIT SPECT for calculating dopamine transporter binding in the striatum and serotonin transporter density in the thalamus- hypothalamus region. Results There was no difference between the quantity of K- complexes, K- alpha- complexes, and sleep spindles in PD patients and in the healthy control group. K- complexes but not sleep spindles decreased over the night in both groups. The number of sleep spindles did not correlate with the dopamine transporter binding in the striatum or the serotonin binding in the thalamic/hypothalamic region. Conclusion K- complexes and sleep spindles are not reduced and do not seem to be related to the degree of dopaminergic degeneration in treated PD patients.Objectives Along with spindles, K- complexes are well known hallmarks of stage 2 (S2) sleep. However, little is known about their quantity in S2 sleep of patients with Parkinson’ s disease (PD). Setting Sleep laboratory, Department of Neurology, University of Vienna, Austria. Patients and methods Whole- night polysomnography (PSG) was performed in twelve treated PD patients and ten healthy controls without history of sleep complaints. The quantity of spontaneous K- complexes, K- alpha- complexes, and sleep spindles in one hour S2 sleep, distributed in four epochs of 15 minutes all through the night, were visually selected and analysed. The quantity and the temporal course of these phasic events were compared with the quantity in age- matched healthy controls. Nine of the twelve PD patients underwent [123I]β - CIT SPECT for calculating dopamine transporter binding in the striatum and serotonin transporter density in the thalamus- hypothalamus region. Results There was no difference between the quantity of K- complexes, K- alpha- complexes, and sleep spindles in PD patients and in the healthy control group. K- complexes but not sleep spindles decreased over the night in both groups. The number of sleep spindles did not correlate with the dopamine transporter binding in the striatum or the serotonin binding in the thalamic/hypothalamic region. Conclusion K- complexes and sleep spindles are not reduced and do not seem to be related to the degree of dopaminergic degeneration in treated PD patients.

关 键 词：帕金森病 神经变性 CITSPECT 睡眠纺锤波 复合波 纹状体 微观结构 多巴 转运体 睡眠研究 

分 类 号：R742.5[医药卫生—神经病学与精神病学]