腔隙性梗死的形状和体积:一项对伴有皮质下梗死和脑白质病的常染色体显性遗传性脑动脉病的3DMRI研究  

Shape and volume of lacunar infarcts: A 3D MRI study in cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy

作　　者：Hervé D. Mangin J.-F. Molko N. H. Chabriat 谢琰臣 

机构地区：[1]Service de Neurologie, H■pital Lariboisiè, 3 rue Ambroise Paré, 75010 Paris, France

出　　处：《世界核心医学期刊文摘（神经病学分册）》2006年第3期50-50,共1页Digest of the World Core Medical Journals:Clinical Neurology

摘　　要：Background and Purpose -The shape and exact size of lacunar infarcts have been investigated only postmortem. Recent imaging techniques based on triangulation and connectivity can now be used for 3D segmentation of cerebral lesions. The shape and size of lacunar infarcts was investigated using these techniques in 10 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients. Methods -We segmented 102 lacunar infarcts on T1-weighted images. The surface of the corresponding set of voxels was computed as a mesh of triangles. Thereafter, the shape of each lesion in 3D was visually analyzed by 2 investigators. Results -The volume of lesions ranged from 10.5 to 1146 mm, with 93%of them having a volume < 500 mm; 83%lacunar infarcts had a spheroid or ovoid shape, but 17%presented as sticks, slabs, or with a complex shape. Lesions with multiple components appeared larger than the others, and a tail extension was noticed in 13 of 102 lesions. Conclusions -These results sugges t the following: (1) most lacunar infarcts in CADASIL have a volume far below one third of that of a sphere of 15 mm in diameter, the upper limit currently used for their identification on 2D imaging; (2) a significant proportion of lacunar infarcts have a shape distinct from the spheroid-ovoid morphology; and (3) les ions with a complex shape may result from the involvement of the largest small a rteries, confluence of ischemic lesions, or secondary tissue degeneration. The s egmentation of lacunar infarcts appears promising to better understand the patho physiology of tissue lesions secondary to small vessel diseases.Background and Purpose -The shape and exact size of lacunar infarcts have been investigated only postmortem. Recent imaging techniques based on triangulation and connectivity can now be used for 3D segmentation of cerebral lesions. The shape and size of lacunar infarcts was investigated using these techniques in 10 cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) patients. Methods -We segmented 102 lacunar infarcts on T1-weighted images. The surface of the corresponding set of voxels was computed as a mesh of triangles. Thereafter, the shape of each lesion in 3D was visually analyzed by 2 investigators. Results -The volume of lesions ranged from 10.5 to 1146 mm, with 93%of them having a volume < 500 mm; 83%lacunar infarcts had a spheroid or ovoid shape, but 17%presented as sticks, slabs, or with a complex shape. Lesions with multiple components appeared larger than the others, and a tail extension was noticed in 13 of 102 lesions. Conclusions -These results sugges t the following: (1) most lacunar infarcts in CADASIL have a volume far below one third of that of a sphere of 15 mm in diameter, the upper limit currently used for their identification on 2D imaging; (2) a significant proportion of lacunar infarcts have a shape distinct from the spheroid-ovoid morphology; and (3) les ions with a complex shape may result from the involvement of the largest small a rteries, confluence of ischemic lesions, or secondary tissue degeneration. The s egmentation of lacunar infarcts appears promising to better understand the patho physiology of tissue lesions secondary to small vessel diseases.

关 键 词：腔隙性梗死 MRI研究 皮质下梗死 脑白质病 缺血性病灶 加权成像 脑部病变 小动脉 影像学技术 三 

分 类 号：R743.3[医药卫生—神经病学与精神病学]