巨大皮肤黑素棘皮瘤  

Giant cutaneous melanoacanthoma

作　　者：Kihiczak G.G. Centuri'on S.A. Schwartz R.A. Lambert W.C. 张宪旗 

机构地区：[1]Dr.Department of Dermatology, New JerseyMedicalSchool,185SouthOrangeAvenue,Newark,N J 07103-2714, United States

出　　处：《世界核心医学期刊文摘（皮肤病学分册）》2005年第5期38-39,共2页Digest of the World Core Medical JOurnals:Dermatology

摘　　要：A 45-year-old male cook was seen for the evaluation and removal of a "mole o n my eye" of steady growth during the previous 6 months. The patient stated that he had had a "brown spot" above his left eye for 17 years prior to its recent e nlargement; it was now partly blocking the vision in his left eye. He denied a h istory or family history of cutaneous tumors, including skin cancer. On examinat ion, a 2.5-cm ×.0.5-cm ×.0.8-cm, horn-like, darkly pigmented, cutaneous no dule was evident extending from the left upper eyelid downwards to below the low er eyelid (Figs 1 and 2). He also had scattered, skin-colored, 2-3-mm cystic papules on his anterior mid-chest. A shave excision specimen was obtained from the eyelid nodule. Microscopic examination demonstrated acanthosis, hyperkeratos is, and papillomatosis (Fig. 3). Large dendritic cells with abundant melanin gra nules were spread throughout the epidermis. In addition, small basaloid or spino us keratinocytes were present in the malpighian layer.A 45-year-old male cook was seen for the evaluation and removal of a 'mole o n my eye' of steady growth during the previous 6 months. The patient stated that he had had a 'brown spot' above his left eye for 17 years prior to its recent e nlargement; it was now partly blocking the vision in his left eye. He denied a h istory or family history of cutaneous tumors, including skin cancer. On examinat ion, a 2.5-cm ×.0.5-cm ×.0.8-cm, horn-like, darkly pigmented, cutaneous no dule was evident extending from the left upper eyelid downwards to below the low er eyelid (Figs 1 and 2). He also had scattered, skin-colored, 2-3-mm cystic papules on his anterior mid-chest. A shave excision specimen was obtained from the eyelid nodule. Microscopic examination demonstrated acanthosis, hyperkeratos is, and papillomatosis (Fig. 3). Large dendritic cells with abundant melanin gra nules were spread throughout the epidermis. In addition, small basaloid or spino us keratinocytes were present in the malpighian layer.

关 键 词：黑素棘皮瘤 基底样细胞 树枝状细胞 乳头瘤样增生 角化过度 上眼睑 黑素颗粒 左侧眼 角质形成细胞 囊样 

分 类 号：R739.5[医药卫生—肿瘤]