日本人阿尔茨海默病患者开角型青光眼的高患病率  

High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease

作　　者：Tamura H. Kawakami H. Kanamoto T. 潘佳鸿 

机构地区：[1]Department of Epidemiology,Research Institute for Radiation Biology and Medicine,Hiroshima University,Japan

出　　处：《世界核心医学期刊文摘（眼科学分册）》2006年第10期6-7,共2页Digest of the World Core Medical Journals:Ophthalmology

摘　　要：The clinical and genetic relationships between Alzheimer’ s disease(AD)and glaucoma remain obscure.The aim of this study was to determine the prevalence of openangle glaucoma(OAG)in patients with AD and whether the apolipoprotein E(APOE)4 allele is associated with AD,with or without OAG,in Japanese.The groups consisted of 172 patients with the diagnostic criteria of AD and 176 age-matched controls.Ophthalmic examinations were conducted,and genomic analysis was performed by PCR and digestion of products with an enzyme.OAG was found in 41(23.8%)of the AD patients,which was a significantly(p=0.0002)higher prevalence than that in the controls(9.9%).Furthermore,there was no significant difference between intraocular pressures(IOPs)in AD patients with OAG and without OAG.The percentage of AD patients who carried an APOE 4 allele(29.5%)was significantly(p=0.0007)higher than that of the controls(9.1%).However,the percentage of AD patients with OAG who carried an APOE 4 allele(35.7%)was not significantly different than that of AD patients without OAG(27.7%,p=0.42).In summary,the prevalence of OAG is high in Japanese patients with AD,suggesting that common factors other than APOE may contribute to the two diseases.The clinical and genetic relationships between Alzheimer' s disease(AD)and glaucoma remain obscure.The aim of this study was to determine the prevalence of openangle glaucoma(OAG)in patients with AD and whether the apolipoprotein E(APOE)4 allele is associated with AD,with or without OAG,in Japanese.The groups consisted of 172 patients with the diagnostic criteria of AD and 176 age-matched controls.Ophthalmic examinations were conducted,and genomic analysis was performed by PCR and digestion of products with an enzyme.OAG was found in 41(23.8%)of the AD patients,which was a significantly(p=0.0002)higher prevalence than that in the controls(9.9%).Furthermore,there was no significant difference between intraocular pressures(IOPs)in AD patients with OAG and without OAG.The percentage of AD patients who carried an APOE 4 allele(29.5%)was significantly(p=0.0007)higher than that of the controls(9.1%).However,the percentage of AD patients with OAG who carried an APOE 4 allele(35.7%)was not significantly different than that of AD patients without OAG(27.7%,p=0.42).In summary,the prevalence of OAG is high in Japanese patients with AD,suggesting that common factors other than APOE may contribute to the two diseases.

关 键 词：阿尔茨海默病 开角型青光眼 酶切消化 载脂蛋白 眼部检查 基因组分析 诊断标准 

分 类 号：R749.161[医药卫生—神经病学与精神病学] R775[医药卫生—临床医学]