人原发性肝癌P53基因缺失和突变  

DELETION AND MUTATION OF P53 GENE IN HUMAN HEPATOCELLULAR CARCINOMA

作　　者：李岱宗[1] 曹宇清[1] 贺丽萍[1] 严根宝[1] 顾健人[1] 

机构地区：[1]上海市肿瘤研究所

出　　处：《肿瘤》1991年第5期195-196,共2页Tumor

摘　　要：在多种人体肿瘤组织中P53基因有缺失,P53基因作为一个抗癌基因,能在体外抑制肿瘤细胞的生长。肿瘤组织中P53基因缺失或发生突变,丧失了抗癌基因的活性,某些突变体还具有协同转化活性。本文分析了12例肝癌及其相应癌旁正常组织P53基因的存在状态,发现3例(25％)P53基因有缺失,3例P53基因有突变。这一结果提示P53基因为人肝癌抗癌基因,它的缺失或突变与肝癌的发生或演进有关。Deletions and mutations of P53 gene occurred frequently in diverse human tumortypes, including human hepatocellular carcinoma. The tumorous and corresponding non-tumorous liver tissue of 12 patients from Qidong County were analyzed. 2 out of the 12samples showed loss of heterozygosity at 17p alleles, while the other one showed chro-mosome rearrangement in this region.No mutation in exon 7were detected in the aforementioned 3 samples by direct sequencing. Mutations between codon 249 and 250 of P53gene were observed in the tumorous tissue of another 3 samples. The sequence analysisof the rest tumorous and non-tumorous tissues is just under way

关 键 词：原发性 肝肿瘤 P53基因 缺失 突变 

分 类 号：R735.702[医药卫生—肿瘤]