冷却方式对冻干脂质体药物的粒径和包封率影响的实验研究  

THE EXPERIMENTAL STUDY ON THE INFLUENCE OF FREEZING METHOD ON THE SIZE AND ENCAPSULATION EFFICIENCY OF THE FREEZE-DRIED LIPOSOME PHARMACEUTICALS

作　　者：刘占杰[1] 肖洪海[1] 苏树强[1] 华泽钊[1] 

机构地区：[1]上海理工大学低温生物研究所,上海200093

出　　处：《工程热物理学报》2002年第5期599-601,共3页Journal of Engineering Thermophysics

基　　金：国家自然科学基金重点基金资助项目(No.59836240)

摘　　要：衡量脂质体药物品质的两个重要指标是脂质体包裹药物的粒径分布和包封率,在冷冻干燥过程中脂质体药物的粒径分布和包封率会发生变化。本文通过实验研究了两种快慢不同冷却方式对脂质体药物冻干后粒径的分布和包封率的影响。In terms of the quality of the liposome Pharmaceuticals, two important performance criteria are the size and the encapsulation efficiency of liposome encapsulated pharmaceuticals. The two criteria dramatically depend on the freeze-drying process. This paper studied the influence of different freezing methods, rapid and slow cooling rates, on the size distribution and the encapsulation efficiency of the freeze-dried liposome pharmaceuticals.

关 键 词：冷却方式 冻干脂质体药物 粒径 包封率 冷冻干燥 冷却速率 药剂学 

分 类 号：TK124[动力工程及工程热物理—工程热物理]