眼表面的防御机制  被引量：9

Defense mechanism of ocular surface</em> <p class='article-op'> <span id="bdshare" class="bdshare_t bds_tools get-codes-bdshare baidufx"><span><span class="bds_more" style="display: block; width: 62px; height: 29px; background: url(/images/share.gif) no-repeat!important; padding: 0;"></span></span></span> </p> <p class="article-source"> <a href ='/article/read.aspx?id=6902480' class='btnTitle btnIsView' target='_blank'><img alt='在线阅读' src='/images/btn-read.png'/></a><a class='btnTitle btnIsView' href="javascript:showdown('HX605lITuHiv44n7ZbvmCp+8BQWwXffFYBQSdpGVDNo=')"><img alt="下载全文" src="/images/btn-down.png" /></a> <input id="hiddowninfo" type="hidden" value="HX605lITuHiv44n7ZbvmCp+8BQWwXffFYBQSdpGVDNo="/> </p> <div class="collect" style="display: none"> <h5>我的收藏</h5> <div class="cnt"> <p> 名 称：<input type="text" name="collTitle" id="collSumTitle" /> </p> <p> 注 释：<input type="text" name="collRemark" id="collSumRemark" /> </p> <p style="text-align: center;"> <a href="javascript:void(0)" onclick="g_collectSumOk();"> <img width="65" height="17" src="/images_new/collect_ok.png" alt="完成" /></a> <a href="javascript:void(0)" onclick="g_collectSumCancel();"> <img width="65" height="17" src="/images_new/collect_no.png" alt="取消" /></a> </p> </div> </div> </div> <form name="wxTransfer" method="post"> <input type="hidden" name="lid" value="" /> <input type="hidden" name="sip" value="" /> <input type="hidden" name="date" value="" /> <input type="hidden" name="co" value="" /> <input type="hidden" name="Title_C" value="" /> <input type="hidden" name="Writers" value="" /> <input type="hidden" name="Name_C" value="" /> <input type="hidden" name="Num" value="" /> <input type="hidden" name="Years" value="" /> <input type="hidden" name="Volumn" value="" /> <input type="hidden" name="GCH" value="" /> <input type="hidden" name="Vol" value="" /> <input type="hidden" name="BookID" value="" /> <input type="hidden" name="SubjectNum" value="" /> <input type="hidden" name="SpecialNum" value="" /> <input type="hidden" name="mirrorName" value="" /> <input type="hidden" name="UserID" value="" /> <input type="hidden" name="UserName" value="" /> <input type="hidden" name="sourceID" value="" /> </form> <script type="text/javascript" src="/scripts/transfer.min.js"></script> <div class="article-detail"> <p class='author'><strong>作　　者：</strong><a href='/writer/article.aspx?id=100000005729909' target='_blank' ><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=A%3d%5b%e6%9d%8e%e5%bf%97%e6%9d%b0%5d' title='李志杰[1]'>李志杰[1]</a> <a href='/zk/search.aspx?key=A%3d%5bC.WayneSMITH%5d' title='C.WayneSMITH'>C.WayneSMITH</a> <em> </em></p><p class='organ'><strong>机构地区：</strong><a href='/organ/article.aspx?id=1204&subid=&showname=&searchtype=' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=S%3d%e6%9a%a8%e5%8d%97%e5%a4%a7%e5%ad%a6%e7%bb%84%e7%bb%87%e7%a7%bb%e6%a4%8d%e4%b8%8e%e5%85%8d%e7%96%ab%e4%b8%ad%e5%bf%83%e7%9c%bc%e7%a7%91%e5%ad%a6%e6%95%99%e7%a0%94%e5%ae%a4' title='[1]暨南大学组织移植与免疫中心眼科学教研室,广州市510632'>[1]暨南大学组织移植与免疫中心眼科学教研室,广州市510632</a> <a href='/zk/search.aspx?key=S%3dSectionofLeukocyteBiology' title='[2]SectionofLeukocyteBiology,BaylorCollegeofMedicine'>[2]SectionofLeukocyteBiology,BaylorCollegeofMedicine</a> <em> </em></p><p class='from'><strong>出　　处：</strong><a href='/journal/summary.aspx?gch=92134X' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=J%3d%5b%e7%9c%bc%e7%a7%91%e6%96%b0%e8%bf%9b%e5%b1%95%5d' title='眼科新进展'>《眼科新进展》</a>2002年第5期297-300,共4页<em>Recent Advances in Ophthalmology</em></p><p class='fund'><strong>基　　金：</strong>.NULL.</p><p class='abstrack'><strong>摘　　要：</strong>　眼表面持续暴露于各种应急状态。为了保护眼表面的完整性并维持角膜的透明状态 ,眼表面将动用多种防御机制。这些防御机制包括 :固有的解剖学屏障、分泌某些化学性杀菌物质和细菌裂解物质 ,如溶菌酶和乳铁蛋白 ,局部分泌Ig A抗体 (s Ig A) ,局部免疫活性细胞反应和局部特异性分子的表达 ,如细胞因子和 Fas配体。眼表在睁眼和闭眼 2种状态下使用 2种完全不同的防御策略。长时间闭眼将导致泪膜组成、起源和代谢的显著改变。这些改变包括 s Ig A、分泌小片、补体成分和炎症介质水平的增高 。<em><Abstrcat>The outer surface of the eye is constantly exposed to a wide array of stress conditions. To protect the integrity or the ocular surface and to retain corneal transparency, a number of defense mechanisms have evolved. These defenses include intrinsic anatomic barriers, secretion of certain chemical bacteriostatics and bacteriolytics such as lysozyme and lactoferrin, local secretary IgA (sIgA) antibody secretion, local immunocompetent cellular responses, and local molecular expressions such as cytokines and Fas ligand. Ocular surface utilizes distinctly two different strategies in open and closed eye conditions. Prolonged eye closure will results in a profound change in the composition, origins and turn over of the tear film. These changes include a marked increase in the level of sIgA, secretary component, complement components and inflammatory mediators as well as the recruitment of polymorphonuclear neutrophil into the tear film.</em></p><p class='subject'><strong>关 键 词：</strong><a href='/subject/article.aspx?id=820546' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e7%9c%bc%e8%a1%a8%e9%9d%a2%5d' title='眼表面'>眼表面</a> <a href='/subject/article.aspx?id=6662912' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e9%98%b2%e5%be%a1%e6%9c%ba%e5%88%b6%5d' title='防御机制'>防御机制</a> <a href='/subject/article.aspx?id=3862351' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%be%ae%e7%94%9f%e7%89%a9%e5%ad%a6%5d' title='微生物学'>微生物学</a> <a href='/subject/article.aspx?id=4694199' target='_blank'><b class='type_ico_id'></b></a><a href='/zk/search.aspx?key=K%3d%5b%e5%85%8d%e7%96%ab%5d' title='免疫'>免疫</a> </p><p class='class'><strong>分 类 号：</strong><a href='/zk/search.aspx?key=C%3dR771' title='R771'>R771</a>[<a href = '/domain/article.aspx?id=507' >医药卫生—眼科</a>] </p> </div> <div id="content_wzxg" name="wzxg" class="article-graph"> <object width="695" height="250" classid="clsid:D27CDB6E-AE6D-11cf-96B8-444553540000" id="FlashID"> <param value="../flash/relation.swf" name="movie"> <param value="high" name="quality"> <param value="opaque" name="wmode"> <param value="6.0.65.0" name="swfversion"> <param value="dataUrl=/ajax/articlerelativegraph.ashx?id=6902480" name="flashVars"> <embed width="695" height="250" src="../flash/relation.swf" type="application/x-shockwave-flash" quality="high" wmode="opaque" flashvars="dataUrl=/ajax/articlerelativegraph.ashx?id=6902480"> </embed> </object> </div> <div class="article-relate-list"> <div class="relate-list"> <p id="ckwx_br"> </p> <h2 name="ckwx" id="ckwx">参考文献：</h2> <div id="listckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jckwx_br"> </p> <h2 name="2jckwx" id="2jckwx">二级参考文献：</h2> <div id="list2jckwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="ohwx_br"> </p> <h2 name="ohwx" id="ohwx">耦合文献：</h2> <div id="listohwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="yzwx_br"> </p> <h2 name="yzwx" id="yzwx">引证文献：</h2> <div id="listyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="2jyzwx_br"> </p> <h2 name="2jyzwx" id="2jyzwx">二级引证文献：</h2> <div id="list2jyzwx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="tbywx_br"> </p> <h2 name="tbywx" id="tbywx">同被引文献：</h2> <div id="listtbywx"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> <div class="relate-list"> <p id="xgqklw_br"> </p> <h2 name="xgqklw" id="xgqklw">相关期刊文献：</h2> <div id="listxgqklw"> <p class='submit'> <img src='/images/loading.gif' width='16' height='16' /> 正在载入数据... </p> </div> </div> </div> </div> <div class="article-about"> <div class="about-box"> <h5 class="name">相关的主题<tt><a class="hide" href="#"></a></tt></h5> <div class="about-list"> </div> </div> <div class="about-box"> <h5 class="name">相关的作者对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> <div class="about-box"> <h5 class="name">相关的机构对象<tt><a class="" href="#"></a></tt></h5> <div class="about-list" style="display: none;"> </div> </div> </div> </div> </div> <script type="text/javascript" src="/scripts/articlerelation.min.js"></script> <script type="text/javascript" src="/scripts/articlerightrelation.min.js"></script> <script type="text/javascript" src="/scripts/articledown.min.js"></script> <div class="layer-box download" id="downloadlayer" style="display: none"> <div class="close"> <a onclick="closedown()" href="javascript:void(0)"> <img src="/images/layer-close.png" width="21" height="21" alt="" /> </a> </div> <h5 class="layer-title">下载全文</h5> <div id="downloadinfo"></div> </div> <div class="layer-box download" id="downloadlayer2" style="display:none;min-height:100px;width:500px;"> <p> <img src="/images/loading2.gif" width="64" height="64"> <span style="font-size:20px;vertical-align:middle;padding-bottom:50px;">正在链接到云南高校图书馆文献保障联盟下载...</span> </p> </div> <script id="bdshare_js" data="type=tools&uid=0" type="text/javascript"></script> <script type="text/javascript"> $(function () { var rd = GetQueryString("rd"); if (rd == "readdown") { var val = $("#hiddowninfo").val(); showdown(val); } $("#bdshare_js").attr("src","http://bdimg.share.baidu.com/static/js/bds_s_v2.js?cdnversion="+Math.ceil(new Date() / 3600000)); }) </script> <div class="layer-bg" style="display: none;"></div> <script type="text/javascript" src="/scripts/login.min.js"></script> <div class="layer-box login" id="divLoginBox" style="display: none;"> <div class="close"><a href="javascript:void(0);" id="btnLoginClose"> <img src="/images/layer-close.png" width="21" height="21" alt="" title="关闭" /></a></div> <h5 class="layer-title">用户登录</h5> <div class="layer-cnt"> <div class="search-list adv-object"> <div class="login-alert" id="divLoginError"></div> <div class="sinput"> <div class="input"><span class="user-ico"></span> <input type="text" id="txtLUsername" name="txtLUsername" maxlength="20"></div> </div> <div class="sinput"> <div class="input"><span class="psw-ico"></span> <input type="password" id="txtLPassword" name="txtLPassword" maxlength="20"></div> </div> <div class="submit"> <input type="button" value="登录" onclick="return normalLogin(loginAfter)" name="" class="btn-s"><input value="IP登录" onclick=" return ipLogin(loginAfter)" type="button" class="btn-c"> </div> </div> </div> </div> <div id="footer"> <p> 云南高校图书馆联盟文献共享服务平台 版权所有© <script type="text/javascript"> document.write(new Date().getFullYear()); </script> </p> <p> 您的IP：216.73.216.229 </p> </div> <input id="hifBaseLog" type="hidden" value="OTIxMzRYOzY5MDI0ODA7Ujc3MTswOzsvYXJ0aWNsZS9kZXRhaWwuYXNweA=="/> <script type="text/javascript"> $(document).ready(function () { $("#loginLoading").load("/user/loginheader.aspx?" + Math.random()); }); </script> <script> var _hmt = _hmt || []; (function () { var hm = document.createElement("script"); hm.src = "//hm.baidu.com/hm.js?36a05ff8f5e8a5be3ff03e1d75c8a9d1"; var s = document.getElementsByTagName("script")[0]; s.parentNode.insertBefore(hm, s); })(); </script> <script> (function (i, s, o, g, r, a, m) { i['GoogleAnalyticsObject'] = r; i[r] = i[r] || function () { (i[r].q = i[r].q || []).push(arguments) }, i[r].l = 1 * new Date(); a = s.createElement(o), m = s.getElementsByTagName(o)[0]; a.async = 1; a.src = g; m.parentNode.insertBefore(a, m) })(window, document, 'script', '//www.google-analytics.com/analytics.js', 'ga'); ga('create', 'UA-2219013-37', 'auto'); ga('send', 'pageview'); </script> </body> </html>