Effects of cysteamine on nociception in mice  

半胱胺对小鼠疼痛感受的影响<英文>

作　　者：Anna CAPASSO Alberto LOIZZO 

机构地区：[1]Department of Pharmaceutical Sciences, University of Salerno, Via Ponte Don Melillo 84084 Fisciano, Salerno,Istituto Superiore di Sanita viale Regina Elena 299 00161 Roma, Italy

出　　处：《Acta Pharmacologica Sinica》2001年第7期29-34,共6页中国药理学报（英文版）

摘　　要：AIM: The present study was carried to study the effects of cysteamine on nociception in mice. METHODS: The pain assays were the hot plate and the tail flick test. RESULTS: When cysteamine, a drug well known as a somatostatin depletor, was administered 1 and 4 but not 24 h before the tests (hot plate, tail flick), the nociceptive threshold was elevated when the drug was administered at high doses (50 and 100 mg/kg) while at a lower dose (10 mg/kg), it was able to elevate the nociceptive threshold in the hot plate test only. In the hot plate as well the tail flick test cysteamine effects are reversed by nalox-one administration and potentiated by morphine administration, whereas neither somatostatin nor cyclo-(7-amino-heptanoyl-Phe-D-Trp-Lys-Thr[Bzl], a reported somatostatin antagonist, changes cysteamine effects. CONCLUSION: These results suggest that cysteamine effects on the nociceptive threshold in the hot plate and tail flick test may be mediated by cysteamine interference with the opioid system.INTRODUCTION Cysteamine (β-mercaptoethylamine) is a thiol com-pound whose biological activities have recently receivedgreat attention, and that can be found in animals whenacetyl coenzyme A is hydrolized by pantethinase.Clinically it has been used in the treatment ofacetaminophen poisoning and in the treatment ofnephropathic cystinosis. It was reported that cys-teamine depletes somatostatin in the stomach, duodenum,pancreas, gut and hypothalamus of rat. Cysteaminewas also found to deplete somatostatin in the

关 键 词：CYSTEAMINE pain measurement ANALGESICS 

分 类 号：R96[医药卫生—药理学]