A NEW HUMAN INTERFERON-γ MUTANT HARBORING EGF RECEPTOR-INTERFERING SEQUENCE POSSESSES HIGH ANTIPROLIFERATIVE ACTIVITY  

作　　者：王晓鸣 李玉英 金奇 张智清 侯云德 

机构地区：[1]Department of Virology,Institute of Microbiology & Epidemiology,Academy of Military Medicine,Beijing 100850,PRC [2]National Laboratory of Molecular Virology and Genetic Engineering,Institute of Virology,Chinese Academy of Preventive Medicine,Beijing 100052,PRC

出　　处：《Progress in Natural Science:Materials International》1991年第2期181-185,共5页自然科学进展·国际材料（英文版）

基　　金：This work was supported by China National Expert Committee for Biotechnology Development.

摘　　要：Human interferon γ(IFN-γ)differs from IFN-α and IFN-β in its gene structure and bio-logical activities,especially in its more active immunoregulating function.Mature IFN-γ iscomposed of 143 amino acids.It was reported that if C-terminal 13 acids of IFN-γ were de-leted,its antiviral activity was 1000 fold lower than that of the intact molecule.In the pre-

关 键 词：INTERFERON-Γ MUTANT EGFR-interfering SEQUENCE ANTIPROLIFERATIVE activity 

分 类 号：N[自然科学总论]