ANTIPROLIFERATIVE

作品数:69被引量:114H指数:6
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相关领域:医药卫生生物学更多>>
相关作者:李晓静钟杭景永奎赵临襄赵璇更多>>
相关机构:教育部中国医科大学中国科学院大学郑州大学更多>>
相关期刊:《离子交换与吸附》《Chemical Research in Chinese Universities》《Chinese Medicine》《Food and Nutrition Sciences》更多>>
相关基金:国家自然科学基金中国博士后科学基金国家高技术研究发展计划上海市青年科技启明星计划更多>>
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N-Benzyl arylamide derivatives as novel and potent tubulin polymerization inhibitors against gastric cancers:Design,structure-activity relationships and biological evaluations
《Chinese Chemical Letters》2025年第2期228-233,共6页Jian Song Shenghui Wang Qiuge Liu Xiao Wang Shuo Yuan Hongmin Liu Saiyang Zhang 
supported by the National Natural Science Foundation of China(Nos.82273782 and U2004123);Training Program for Young Key Teachers of Colleges and Universities in Henan Province(No.2023GGJS008)。
In this work,we employed a ring-opening strategy to develop a series of novel N-benzyl arylamide derivatives as tubulin polymerization inhibitors.Notably,13n(MY-1388)exhibited remarkable antiproliferative potency on f...
关键词:TUBULIN Colchicine binding site CA-4 N-Benzyl arylamide Antiproliferative activities 
The Anticancer Potential of Quassinoids-A Mini-Review
《Engineering》2024年第7期27-38,共12页Cai Lu Si-Nan Lu Di Di Wei-Wei Tao Lu Fan Jin-Ao Duan Ming Zhao Chun-Tao Che 
supported by the National Natural Science Foundation of China(82274085);the Natural Science Foundation of Jiangsu Province(BK20220478);the Natural Science Foundation of Jiangsu Higher Education institutions of China(22KJB360010).
The anticancer potential of quassinoids has attracted a great deal of attention for decades,and scientific data revealing their possible applications in cancer management are continuously increasing in the literature....
关键词:Quassinoid Anticancer potential Antiproliferative mechanism Safety evaluation Synergistical combination with anticancer DRUGS 
Persicaria lanigera (Polygonaceae) leaf extract exhibits antiulcerogenic and antiproliferative activities against acetic acid-induced ulcerative colitis and cotton pellet-induced granuloma tissue in rats
《Asian Pacific Journal of Tropical Biomedicine》2024年第7期269-278,共10页Meshack Antwi-Adjei Ernest Obese Emmanuel Awintiig Adakudugu Benjamin Aboagye Daniel Anokwah Akua Afriyie Karikari Roberta Antwi-Adjei Elvis Ofori Ameyaw 
Objective:To assess the effect of leaf extract of Persicaria lanigera on cotton pellet-induced granuloma tissue formation and acetic acid-induced ulcerative colitis.Methods:Rats were randomly divided into six groups:n...
关键词:Colitis Persicaria lanigera Antioxidant Cotton pellets Mast cells Granuloma tissue formation 
The contribution of different polyphenol compositions from chokeberry produced in China to cellular antioxidant and antiproliferative activities
《Food Science and Human Wellness》2023年第5期1590-1600,共11页Ningxuan Gao Xu Si Wenzhong Han Ersheng Gong Chi Shu Jinlong Tian Yuehua Wang Jiyue Zhang Binxu Li Bin Li 
supported by the National Natural Science Foundation of China (31671863);Young and Middle-aged Technological Innovation Talent Support Program of Shenyang Science and Technology Bureau (RC170247);Innovative Talent Support Program for Institution of Higher Learning of Liaoning Province (LR2017038)。
Abundant polyphenols make chokeberry have beneficial antioxidant and antiproliferative activity. In order to explore the contribution of different polyphenols in chokeberry to these activities, this study was conducte...
关键词:Chokeberry Anthocyanins PROANTHOCYANIDINS ANTIOXIDANT ANTIPROLIFERATION 
Identification of Cyprus propolis composition and evaluation of its antimicrobial and antiproliferative activities
《Food Bioscience》2023年第1期439-446,共8页Sual Tatlısulu Erkay Ozgor 
funded by Cyprus International University(Grant number:2019-03).
Propolis is a raw natural product produced by Apis mellifera for hive defence.Scientists have also investigated propolis in terms of different biological activities such as antimicrobial and anticancer effects for man...
关键词:PROPOLIS GC-MS MCF-7 MDA-MB-231 E.COLI P.Aeruginosa 
Garcinia spp:Products and by-products with potential pharmacological application in cancer
《Food Bioscience》2022年第6期2138-2151,共14页Lavínia de C.Brito André Mesquita Marques Flávia da Cunha Camillo Maria Raquel Figueiredo 
the Farmanguinhos Institute of Technology in Pharmaceuticals/Oswaldo Cruz Foundation(FIOCRUZ).
The Garcinia genus belongs to the Clusiaceae family and is composed of approximately 240 species,distributed throughout the tropical regions,with a significant representation in Brazil.Their edible fruits have a high ...
关键词:CLUSIACEAE Anticarcinogenic ANTIPROLIFERATIVE CYTOTOXIC 
Antiproliferative piperidine alkaloids from giant taro(Alocasia macrorrhiza)被引量:1
《Chinese Journal of Natural Medicines》2022年第7期541-550,共10页GAO Wei WANG Yi WANG Ru WANG Yi-Hai XU Jing-Wen HE Xiang-Jiu 
supported by the National Natural Science Foundation of China(No.82173698);the Guangdong Province Universities and Colleges Pearl River Scholar Funded Scheme(2017);the Pearl River S&T Nova Program of Guangzhou(No.201806010169).
The rhizome of giant taro(Alocasia macrorrhiza(L.)Schott),which is a highly adaptable wild plant,is a traditional Chinese herbal medicine.In the current study,the antiproliferative constituents of giant taro were inve...
关键词:Giant taro Alocasia macrorrhiza Piperidine alkaloids ANTIPROLIFERATIVE APOPTOSIS 
Evaluation of Subacute Toxicity of Hydroethanolic Extracts Combinations from Gnetum africanum (Welv.) and Gnetum buchholzianum (Engl.) (Genetaceae) Leaves: Two Botanical with Antiproliferative and Antioxidant Potential
《Open Journal of Applied Sciences》2022年第6期944-963,共20页Bertin Sone Enone Jean-Pierre Ngene Angèle Foyet Fondjo Charles Christian Ngoule Loé Gisèle Etame Loick Pradel Kojom Foko Christophe Manz Koule François Siewe Ronald Bidingha Goufani Josiane Etang Albert Mouelle Sone 
This study was conducted to assess the toxic effect of hydroethanolic extract combinations of Gnetum africanum Welv. leaves and Gnetum buchholzianum Engl. (Gnetaceae) in experimental rats to test the validity of the t...
关键词:Gnetum africanum Gnetum buchholzianum Subacute Toxicity Oxidative Stress Albino Rats 
Simultaneous Screening and Analysis of Anti-inflammatory and Antiproliferative Compounds from Euphorbia maculata Combining Bio-affinity Ultrafiltration with Multiple Drug Targets被引量:3
《Journal of Analysis and Testing》2022年第2期98-110,共13页Tojofaniry Fabien Rakotondrabe Min-Xia Fan Yong-Li Zhang Ming-Quan Guo 
Euphorbia maculata has long been used for managing different impairments in Asian countries.However,its antioxidant,anti-inflammatory and antiproliferative potentialities,along with its potential bioactive compounds r...
关键词:Euphorbia maculata Antioxidant Anti-infl ammatory ANTIPROLIFERATIVE UF-UPLC-QTOF-MS/MS Multipotent compounds 
Indigestible fraction of guava fruit:Phenolic profile,colonic fermentation and effect on HT-29 cells
《Food Bioscience》2022年第2期563-571,共9页Francisco J.Blancas-Benitez Jara P´erez-Jim´enez JAdriana Sa˜nudo-Barajas Nuria E.Rocha-Guzm´an Gustavo A.Gonz´alez-Aguilar Juscelino Tovar Sonia G.S´ayago-Ayerdi 
FJBB thanks Consejo Nacional de Ciencia y Tecnología,M´exico(CONACyT)for the scholarship(378371)granted.
Guava fruit is rich in phenolic compounds(PCs),whose metabolic fate has not been explored.Non-digestible carbohydrates and PCs in whole guava(WG)and seedless guava(SG)were submitted to an in vitro colonic fermentation...
关键词:Short chain fatty acids(SCFA) Phenolic compounds Indigestible fraction In vitro colonic fermentation ANTIPROLIFERATIVE Psidium guajava L 
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