胃癌、不典型增生、萎缩性胃炎及浅表性胃炎血硒水平与抗氧化酶的测定  

DETERMINATION OF SERUM SELENIUM AND ACTIVITIES OF ANTIOXIDASES IN PATIENTS WITH MALIGNANT AND BENIGN GASTRIC DISEASES

作　　者：张廷雨[1] 史奎雄[1] 程五凤[1] 潘碧霞[1] 许秀娴 

机构地区：[1]上海第二医科大学医学营养学教研室

出　　处：《肿瘤》1991年第4期162-166,共5页Tumor

摘　　要：自由基在癌症发生发展过程中的作用已引起了人们的广泛重视。硒是人体内一种必需微量元素,其清除自由基抗氧化的作用是硒防癌的重要机理。为了探讨肿瘤发生发展过程中血硒及抗氧化状态的变化,根据Correa等人提出的人类肠型胃癌发展模型,我们选择了与胃癌发生发展过程中有一定关系的浅表性胃炎、萎缩性胃炎、不典型增生和胃癌患者作为观察对象,对其血硒、抗氧化酶活性、脂质过氧化物浓度及外周血自然杀伤细胞活力进行了测定,观察它们随胃粘膜病变的变化。A group of 84 patients with superficial gastritis (SG), chronic atrophic gastritis(CAG),atrophic gastritis with dysplasia(Dys) and gastric cancer (GC), were tested forserum selenium (Se) and activity of antioxidases. The serum Se and activity of naturalkiller cell(NKC) in GC, Dys and CAG patients were lower than those in normal control(NC) (P<0. 01 and <0. 05 respectively),while serum superoxide dismutase (SOD) andmanganese superoxide dismutase (Mn SOD) and lipid peroxide (LPO) in GC and CAGwere higher than those in NC(P<0.05 for all items). Serum Se level showed a positivecorrelation with NKC activity and a negative one with LPO and SOD. It is postulatedthat a correlation existed between serum Se level and antioxide status and NKC inpatients with gartric diseases.

关 键 词：胃肿瘤 萎缩性胃炎 浅表性胃炎 血硒 抗氧化酶 

分 类 号：R735.202[医药卫生—肿瘤] R573.302[医药卫生—临床医学]