Alzheimer病的MRI定量研究  

Quantitative Study of MR Imaging in Patients with Alzheimer Disease

作　　者：张雪宁[1] 陈希颖[1] 冯丽莎[2] 薛新生[1] 杨连海[1] 

机构地区：[1]天津医科大学第二医院放射科,300211 [2]天津医科大学第二医院神经内科,300211

出　　处：《天津医药》2002年第9期522-523,F004,共3页Tianjin Medical Journal

基　　金：天津市自然科学基金资助项目 (项目编号 :003606511)

摘　　要：目的 :寻找可预测Alzheimer病 (Alzheimerdisease ,AD)的神经影像学指标。方法 :对20名AD患者和20名健康对照者进行MRI测量 ,包括 :两侧海马结构、杏仁核、内嗅皮层。所得数值经部分颅内体积标准化处理 ,然后用社会科学统计程序行统计学分析。结果 :AD患者上述脑实质结构均明显萎缩 ,有效判别指标依次为 :内嗅皮层、海马结构、杏仁核。结论Objective:To identify the neuroimaging determinants which could predict the occurrence of Alzheimer disease(AD) Methods:The findings of MRI in 20 patients with AD and 20 normal controls were compared by means of quantitative measurement of some indicators The indicators included bilateral hippocampal formations(HF),amygdala(AMY) and endorhinal cortices(EC) Results:The indicators in patients with AD were significantly atrophied The indicators that could be discriminated were EC,HF and AMY in proper order Conclusion:The above MRI measurements are important predictors in discriminating patients with AD from normal controls

关 键 词：痴呆 阿尔茨海默病 磁共振成像 AD 诊断 内嗅皮层 海马 杏仁核 

分 类 号：R749.1[医药卫生—神经病学与精神病学]