人体口服乙醇后唾液和全血中乙醛含量的测定  

Determination of acetaldehyde in saliva and blood following oral ethanol administration

作　　者：李俊杰[1] 

机构地区：[1]暨南大学医学院第一附属医院,广东广州510630

出　　处：《中国医院药学杂志》2002年第10期590-592,共3页Chinese Journal of Hospital Pharmacy

摘　　要：目的 :研究人体单剂量口服乙醇后 ,乙醇在体内的毒性代谢产物乙醛在唾液和全血中的浓度 时间变化过程。方法 :采用高效液相色谱荧光法测定 10名健康受试者单剂量口服乙醇 0 .3g·kg-1后 4h内唾液和全血中的乙醛浓度经时过程。结果 :乙醛在唾液中的Cmax(11.5± 2 .2 ) μmol·L-1,AUC(140 2 .7± 44 7.4)min·μmol·L-1;乙醛在全血中的Cmax(1.6 8± 0 .2 5 )μmol·L-1,AUC(176 .8± 41.4)min·μmol·L-1。结论OBJECTIVE To study the concentration-time procedure of salivary and blood acetaldehyde in individuals following oral ethanol administration, which is the toxic metabolite of ethanol.METHODS Ten volunteers were given an oral acute dose of 0.3 g ethanol·kg -1 body weight. Salivary and blood acetaldehyde concentrations were measured using HPLC with fluorescence detection over a period of 240 min.RESULTS Salivary acetaldehyde C max and AUC were ( 11.5± 2.2) μmol·L -1;and ( 1402.7± 447.4) min·μmol·L -1 respectively; Blood acetaldehyde C max and AUC were 1.68± 0.25 μmol·L -1 and ( 176.8± 41.4) min·μmol·L -1 respectively.CONCLUSION Compared with acetaldehyde concentrations in blood, acetaldehyde concentrations in saliva were significantly higher after ethanol ingestion.

关 键 词：乙醛 唾液浓度 全血浓度 高效液相色谱法 上消化道肿瘤 流行病学 

分 类 号：R73－31[医药卫生—肿瘤]