The yins and yangs of ceramide  

作　　者：KAMAL SHARMA YUFANG SHI(Department of Immunology, Jerome H.Holland Laboratory, American Red Cross, 15601 Crabbs Branch Way,Rockville, MD 20855) 

出　　处：《Cell Research》1999年第1期1-10,共10页细胞研究（英文版）

摘　　要：Since their discovery over 100 years ago, sphingolipids have caught the eyes and the imagination of scientists.Modern science has made many new insights on the cell biology and day-to-day functions of many integral sphingolipids, especially those of ceramide. Ceramide is recognized as a vital second messenger in the signal transduction process mediated by receptors of many cytokines and growth factors.A great part of our current understanding of ceramide has been achieved from apoptosis-related studies, however recent data in the fields of immunology, endocrinology and neurobiology, also suggest a fundamental involvement of ceramide in the onset of diseases. Therefore, understanding the biology of ceramide could be a key to unraveling many biological mechanisms and provide information for the treatment of some common diseases.

关 键 词：Cermide SPHINGOMYELINASE SIGNAL TRANSDUCTION 

分 类 号：Q257[生物学—细胞生物学] R362[医药卫生—病理学]