SPHINGOMYELINASE

作品数：5被引量：19H指数：2
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相关领域：医药卫生更多>>
相关作者：许淑萍更多>>
相关机构：中山医学大学更多>>
相关期刊：《Acta Pharmacologica Sinica》《World Journal of Gastroenterology》《Signal Transduction and Targeted Therapy》《Cell Research》更多>>
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Rough operators: sphingomyelinase inhibitors spike NK cells to kill cancer
《Signal Transduction and Targeted Therapy》2023年第9期3892-3893,共2页Mattias Carlsten Yenan T.Bryceson 
This work was supported by grants from the Swedish Cancer Foundation and Swedish Research Council(to M.C.and Y.T.B.);the Knut and Alice Wallenberg Fellows program(to Y.T.B.).
In a recent study published in Nature Immunology,Zheng et al.discovered that intratumoral NK cells were smooth and rounded as opposed to the typical vili-rich,rougher surface of normal NK cells.1 This phenotype was li...
关键词：MYELIN IMPAIRED CANCER 
Vam3, a resveratrol dimer, inhibits cigarette smoke- induced cell apoptosis in lungs by improving mitochondrial function被引量：5
《Acta Pharmacologica Sinica》2014年第6期779-791,共13页Ling-ling XUAN Ji SHI Chun-suo YAO Jin-ye BAI Feng QU Jin-lan ZHANG Qi HOU 
Aim： To investigate the effects of Vam3 （a resveratrol dimer extracted from Vitis amurensis Rupr） on cigarette smoke （CS）-induced cell apoptosis in lungs in vitro and in vivo and the underlying mechanisms of acti...
关键词：Vam3 RESVERATROL lung bronchial epithelial cell cigarette smoking apoptosis Bax MITOCHONDRIA CERAMIDE SPHINGOMYELINASE 
Increase in sphingolipid catabolic enzyme activity during aging被引量：2
《Acta Pharmacologica Sinica》2009年第10期1454-1461,共8页Santosh J SACKET Hae-young CHUNG Fumikazu OKAJIMA Dong-soon IM 
Aim： To understand the contribution of sphingolipid metabolism and its metabolites to development and aging. Methods： A systemic analysis on the changes in activity of sphingolipid metabolic enzymes in kidney, liver...
关键词：AGING SPHINGOLIPID METABOLISM SPHINGOMYELINASE CERAMIDASE sphingomyelin synthase ceramide synthase 
Exogenous sphingomyelinase causes impaired intestinal epithelial barrier function被引量：12
《World Journal of Gastroenterology》2007年第39期5217-5225,共9页Jürgen Bock Gerhard Liebisch Joachim Schweimer Gerd Schmitz Gerhard Rogler 
grants from the University of Regensburg, as part of the ReForM-program, and from the German Research Foundation DFG (BO 2529/2-1) to JB
AIM: To test the hypothesis that hydrolysis of sphingomyelin to ceramide changes the composition of tight junctions (TJs) with increasing permeability of the intestinal epithelium. METHODS: Monolayers of Caco-2 cells ...
关键词：CERAMIDE CHOLESTEROL TIGHT-JUNCTION Caco-2 cells Permeability Inflammatory bowel disease 
The yins and yangs of ceramide
《Cell Research》1999年第1期1-10,共10页KAMAL SHARMA YUFANG SHI(Department of Immunology, Jerome H.Holland Laboratory, American Red Cross, 15601 Crabbs Branch Way,Rockville, MD 20855) 
Since their discovery over 100 years ago, sphingolipids have caught the eyes and the imagination of scientists.Modern science has made many new insights on the cell biology and day-to-day functions of many integral sp...
关键词：Cermide SPHINGOMYELINASE SIGNAL TRANSDUCTION 
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